{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:08:58Z","timestamp":1788966538108,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antroduodenal manometry (ADM) is the gold standard for diagnosing myopathy and neuropathy in patients with upper gastrointestinal (GI) disorders. However, ADM is invasive and costly. Body surface gastric mapping (BSGM) has emerged as a non\u2010invasive test to assess gastric function. This study evaluates the correlation between BSGM and ADM in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinically indicated ADM was performed using high\u2010resolution water\u2010perfused motility catheters, with simultaneous BSGM. Real\u2010time symptoms were tracked using a validated symptom logging app at 15\u2010min intervals, and Nausea Severity Scale (NSS) scores were recorded. Protocols involved a 2\u2009h fast, provocative testing, a meal, and over 1\u2009h of post\u2010prandial recordings. ADM tracings were categorized into neuropathy, myopathy, post\u2010prandial hypomotility, or normal. BSGM metrics included principal gastric frequency, BMI\u2010adjusted amplitude, and Rhythm Index. Gastric emptying data were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen subjects were recruited (13 female; ages 10\u201319\u2009years, BMI 20.6\u2009\u00b1\u20093.5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). ADM results showed neuropathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), myopathic CIPO (myopathy) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), post\u2010prandial hypomotility (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), and normal motility (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Patients with neuropathy had lower rhythm stability (0.16\u2009\u00b1\u20090.03 vs. 0.38\u2009\u00b1\u20090.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), accompanied by higher nausea scores (8.2\u2009\u00b1\u20091.2 vs. 3.15\u2009\u00b1\u20092.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and bloating (7.3\u2009\u00b1\u20090.9 vs. 2.1\u2009\u00b1\u20092.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). ADM neuropathy correlated completely with dysrhythmia on BSGM. Normal ADM were consistent with normal BSGM in 83.3% of cases. Delayed gastric emptying did not correlate with a neuropathic diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dysrhythmic BSGM phenotype reliably identified gastrointestinal neuropathy with identical results to ADM, with significant correlations to nausea and bloating severity. This study supports considering BSGM as an actionable biomarker when performing ADM is not feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70087","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T22:20:38Z","timestamp":1748902838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuropathic Gastroduodenal Disorders Can Be Diagnosed by Non\u2010Invasive Body Surface Gastric Mapping: A Comparison With Antroduodenal Manometry"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5665-5743","authenticated-orcid":false,"given":"Christian","family":"Sadaka","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghong","family":"Xu","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain J.","family":"Benitez","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Orians","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Bowerman","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Dourlain","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Skaggs","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly G.","family":"Konka","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexi","family":"Roshkovan","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology &amp; Nutrition The Children's Hospital of Philadelphia  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-5707","authenticated-orcid":false,"given":"Gayl","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Calder","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"},{"name":"Alimetry Ltd.  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