{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:59:44Z","timestamp":1772765984029,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>During pre\u2010bariatric surgery evaluation, we routinely perform objective testing for GERD (endoscopy, pH monitoring if no reflux esophagitis found) with high\u2010resolution manometry (HRM) and functional lumen imaging probe (FLIP) to evaluate esophageal motility. In this study, we aimed to identify differences in FLIP metrics between obese patients with and without GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed our clinical database of obese patients evaluated for bariatric surgery, including surgery\u2010na\u00efve patients and patients who had sleeve gastrectomy (SG) or Roux\u2010en\u2010Y gastric bypass (RYGB) that resulted in inadequate weight loss. We recorded GERD symptoms, HRM findings, and FLIP metrics (EGJ\u2010diameter, distensibility index, and contractile response patterns). Patients with reflux esophagitis or acid exposure time (AET) &gt;\u20096% were considered GERD+; those with AET \u2264\u20096% were deemed GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      We included 160 patients (mean age 50.2\u2009\u00b1\u200912.4\u2009years; 79% women; 66 surgery\u2010na\u00efve) (29 GERD\u2212, 37 GERD+), 70 SG (20 GERD\u2212, 50 GERD+), 24 RYGB (16 GERD\u2212, 8 GERD+). FLIP abnormalities were frequent, including reduced EGJ opening (REO) (12.1% surgery\u2010na\u00efve, 14.3% SG, 12.5% RYGB) and abnormal contractile response (59.1% surgery\u2010na\u00efve, 71.4% SG, 62.5% RYGB). FLIP differences were found between GERD+ and GERD\u2212 patients: REO (8.0% vs. 30.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and BCR (2.0% vs. 15.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) were both less frequent in GERD+ than in GERD\u2212 SG patients. SRCR was more frequent in GERD\u2212 than in GERD+ surgery\u2010na\u00efve patients (31.0% vs. 5.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While FLIP differences between GERD\u2212 and GERD+ patients exist, there were no FLIP metrics that clearly predicted GERD in obese patients either before or after bariatric surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70091","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T02:20:44Z","timestamp":1748571644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differences in Functional Lumen Imaging Probe (\n                    <scp>FLIP<\/scp>\n                    ) Panometry Patterns Among Obese and Bariatric Surgery Patients With and Without Gastroesophageal Reflux Disease (\n                    <scp>GERD<\/scp>\n                    )"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-117X","authenticated-orcid":false,"given":"Anh D.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambreen","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Health Science Center College of Medicine  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashton","family":"Ellison","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanakyaram A.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Davis","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Medical &amp; Surgical Weight Loss Management  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-2807","authenticated-orcid":false,"given":"Rhonda F.","family":"Souza","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vani J. A.","family":"Konda","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5635-5386","authenticated-orcid":false,"given":"Stuart J.","family":"Spechler","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Center for Esophageal Diseases Baylor University Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41703.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14750"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.09.030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2359-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3902-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000967"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10089"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010021\u201008625\u20105"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2020.0999"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001139"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-008-9474-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330616"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000773"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002387"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.01.069"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20117"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12344"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12218"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13240"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14943"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-06925-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001532"},{"issue":"7","key":"e_1_2_11_27_1","first-page":"649","article-title":"Measuring Gastroesophageal Reflux Disease: Relationship Between the Health\u2010Related Quality of Life Score and Physiologic Parameters","volume":"64","author":"Velanovich V.","year":"1998","journal-title":"American Surgeon"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14116"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1222-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-0040-3"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.04.049"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14192"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.030"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2011.01258.x"}],"container-title":["Neurogastroenterology &amp; 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