{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:31:34Z","timestamp":1793349094034,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aim to investigate the long\u2010term clinical anorectal outcomes and anorectal physiology in patients treated non\u2010surgically for minor types of anorectal malformations (ARM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included 79 non\u2010surgically treated patients born with minor types of ARM. We investigated constipation and fecal incontinence according to the Rome IV criteria, as well as anorectal physiology using anorectal manometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Of all patients, 60% reported no constipation and no fecal incontinence, 38% experienced constipation, and 2% had fecal incontinence. All patients could contract the external anal sphincter and the puborectal muscle, both voluntarily and involuntarily, and 94% possessed a functional internal anal sphincter. The mean anal sensibility was 2.5\u2009mA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>The long\u2010term anorectal outcomes of non\u2010surgically treated patients diagnosed with minor types of ARM seem optimal. Most of these patients experience no constipation and fecal incontinence; some experience constipation and relatively seldom fecal incontinence. Furthermore, most patients possess all the known fecal continence mechanisms. This study demonstrates that patients with minor ARM who received non\u2010surgical treatment can achieve optimal anorectal function outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70093","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T01:58:27Z","timestamp":1749434307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Clinical and Physiological Outcomes in Patients Treated Non\u2010Surgically for Anorectal Malformations"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-0900","authenticated-orcid":false,"given":"Venla E. C.","family":"den Hollander","sequence":"first","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"Division of Pediatric Surgery, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffie","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Trzpis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"Division of Geriatrics, Department of Internal Medicine, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M. A.","family":"Broens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"Division of Pediatric Surgery, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.08.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103468(92)90113\u2010l"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(82)80126-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.10.051"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.09.010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010010\u20102697\u2010z"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000576"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002121"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2014.09.038"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182a42d16"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010018\u20103023\u20109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16060"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.04.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.09.074"},{"key":"e_1_2_12_16_1","unstructured":"V. E. C.Den Hollander J. E.Jonker M.Trzpis andP. M. A.Broens \u201cInvestigation of Fecal Continence Mechanisms in Patients Suffering Fecal Incontinence After Treatment for Anorectal Malformations \u201dsubmitted."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00491-8"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103468(95)90064\u20100"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.08.025"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.055"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31826e4a38"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14983"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12302"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad439"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103468(92)90309\u2010u"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16101"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.70093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:50:38Z","timestamp":1793346638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,8]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/nmo.70093"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70093","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,8]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70093"}}