{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:06:54Z","timestamp":1787580414579,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CVU"],"award-info":[{"award-number":["CVU"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["1141922"],"award-info":[{"award-number":["1141922"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n IBS is multifactorial; however, elucidating its underlying mechanisms is crucial for advancing in its diagnosis and management.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n Evaluate molecular processes related to oxidative stress (OS) and inflammation in IBS and its subtypes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty Rome III\u2010IBS outpatients and 30 controls were studied for OS biomarkers, including malondialdehyde (MDA), protein carbonyls (PC), reduced glutathione (GSH), and oxidized glutathione (GSSG). Also, serum interleukins (IL\u201010, IL\u20104, TNF\u2010\u03b1, IL\u20106), and the nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells (NF\u2010\u03baB), nuclear factor erythroid 2\u2010related factor 2 (Nrf2), and nicotinamide\u2010adenine\u2010dinucleotide phosphate (NADPH) catalytic subunit gp91\n phox<\/jats:sup>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In IBS vs. controls there were higher MDA: 4.44 \u00b1\u20091.76 vs. 2.42 \u00b1\u20090.5 nmol\/mg\/protein (\n p<\/jats:italic>\n <\u20090.01); GSSG: 57.17 \u00b1\u200917.49 vs. 42.73 \u00b1\u200914.26 \u03bcM (\n p<\/jats:italic>\n <\u20090.01); and lower GSH: 26.17 \u00b1\u200912.36 vs. 38.47 \u00b1\u200916.71 \u03bcM (\n p<\/jats:italic>\n <\u20090.01). Also, an imbalance in pro\u2010 and anti\u2010inflammatory interleukins (\n p<\/jats:italic>\n <\u20090.01); and higher NF\u2010\u03baB: 5.33 \u00b1\u20093.39 vs. 3.08 \u00b1\u20091.19 (\n p<\/jats:italic>\n =\u20090.01); gp91\n phox<\/jats:sup>\n : 4.28 \u00b1\u20091.81 vs. 3.29 \u00b1\u20091.03 (\n p<\/jats:italic>\n <\u20090.05); and lower Nrf2: 3.87 \u00b1\u20092.9 vs. 7.56 \u00b1\u20092.59 (\n p<\/jats:italic>\n <\u20090.05). Additionally, there were no significant differences between the IBS subtypes, nor according to severity. Finally, in IBS\u2010C, MDA correlated with IL\u20104, TNF\u2010\u03b1 with IL\u201010; and in IBS\u2010D, GSH correlated with IL\u20104 and no differences in transcription factors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The data demonstrate an alteration in the homeostasis of the cellular redox state in IBS. Also, in IBS\u2010D, the antioxidant effect counteracts the low\u2010grade inflammation, whereas in IBS\u2010C, it is mainly driven by interleukins.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.70097","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:34:49Z","timestamp":1750638889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal Homeostasis in the Redox State and Related Signaling Pathways, in Irritable Bowel Syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"A. S.","family":"Morales\u2010Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Laboratory of Liver, Pancreas and Motility (HIPAM), Department of Experimental Medicine Dr. Ruy P\u00e9rez Tamayo Faculty of Medicine, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"},{"name":"Postgraduate School in Experimental Biology, Directorate of Biological and Health Sciences (DCBS) Universidad Aut\u00f3noma Metropolitana (UAM)\u2010Unidad Iztapalapa Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alarc\u00f3n\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences Universidad Aut\u00f3noma Metropolitana (UAM)\u2010Unidad Iztapalapa Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Luna\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Basic Research Instituto Nacional de Geriatr\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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