{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:33:27Z","timestamp":1766748807391,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020306","name":"Steigerwald Arzneimittelwerk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>STW 5\u2010II has been shown to improve numerous symptoms in functional dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if the herbal medicinal product STW 5\u2010II may improve gastric gas transit and tolerance in patients with functional dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a parallel, randomized, double\u2010blinded, placebo\u2010controlled study, a gas challenge test was performed in 32 patients with functional dyspepsia and bloating after 2\u2009weeks of treatment with (a) STW 5\u2010II and (b) placebo. The challenge test consisted of continuous infusion of gas into the stomach (100\u2009mL\/min for 15\u2009min) with simultaneous nutrient perfusion (315\u2009kcal for 15\u2009min, 210\u2009mL final volume). Gas evacuation, symptom perception, and abdominal distension were continuously registered for 90\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gastric gas infusion was followed by a progressive start of gas evacuation from the rectum that was significantly accelerated when patients were on STW 5\u2010II (319\u2009\u00b1\u200981\u2009mL after 20\u2009min infusion start), compared to placebo (80\u2009\u00b1\u200939\u2009mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.015), but this difference declined during the following 90\u2009min of gas evacuation (final gas retention 470\u2009\u00b1\u2009160 and 662\u2009\u00b1\u2009179, STW 5\u2010II and placebo, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.431). Gas infusion was associated with a significant rise and posterior progressive decline in abdominal symptom perception (mainly bloating) that was significantly lower in patients treated with STW 5\u2010II (mean score increment 0.8\u2009\u00b1\u20090.4) than in patients treated with placebo (score increment 2.1\u2009\u00b1\u20090.4; <jats:italic>p<\/jats:italic>\u2009=\u20090.036). There were no significant differences in abdominal distension between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>STW 5\u2010II improves tolerance to gastric gas in patients with functional dyspepsia and may be beneficial for the treatment of gas\u2010related abdominal symptoms like bloating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>EudraCT number: 2019\u2010003976\u201038<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70123","type":"journal-article","created":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T18:39:42Z","timestamp":1753036782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of STW 5\u2010II (Iberogast\u2010N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO\u20102 Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Ariadna","family":"Aguilar","sequence":"first","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Autonomous University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alcala\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Barber","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-5033","authenticated-orcid":false,"given":"Javier","family":"Santos","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Lobo","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-1492","authenticated-orcid":false,"given":"Carolina","family":"Malagelada","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-6270","authenticated-orcid":false,"given":"Jordi","family":"Serra","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30469-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14229"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15167"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14333"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-00924-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.067"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00875.x"},{"key":"e_1_2_11_10_1","article-title":"Responses to Gastric Gas in Patients With Functional Gastroduodenal Disorders","volume":"4","author":"Caballero N.","year":"2017","journal-title":"United European Gastroenterology Journal"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"18","article-title":"Transit and Tolerance to Gastric Gas in Patients With Functional Dyspepsia: Effects of Nutrients Intake","volume":"30","author":"Caballero N.","year":"2018","journal-title":"Neurogastroenterology and Motility"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535672"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01232.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156167"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14755"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154996"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13408"},{"issue":"7748","key":"e_1_2_11_18_1","first-page":"698","article-title":"CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials","volume":"340","author":"Schulz K. 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