{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:10:10Z","timestamp":1760832610139,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fecal incontinence (FI) is a prevalent and multifactorial disorder, often associated with anal sphincter dysfunction. Transient anal sphincter relaxations (TASR) have been proposed as a contributing factor in FI, though their significance remains unclear. This study aimed to assess the prevalence and clinical impact of TASR using high\u2010definition anorectal manometry (3D\u2010HD ARM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study including consecutive FI patients undergoing 3D\u2010HD ARM. TASR was defined as a resting pressure drop below 15\u2009mmHg lasting &gt;\u200915\u2009s. Manometric parameters, structural assessments, and clinical scores were compared between TASR and non\u2010TASR groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 62 FI patients (74.2% female, mean age 60\u2009years), TASR was detected in 14.5% (95% CI 0.06\u20130.25). TASR patients exhibited significantly lower maximum squeeze pressure (68.5\u2009\u00b1\u200925.6 vs. 105.3\u2009\u00b1\u200956.1\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and reduced anal pressure during cough (54.8\u2009\u00b1\u200928.5 vs. 85.2\u2009\u00b1\u200935.9\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). TASR was also associated with pelvic floor akinesia (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and rectoanal coordination disorders (<jats:italic>p<\/jats:italic>\u2009=\u20090.037), though no significant structural differences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TASR was identified in 15% of FI patients, with associated anal sphincter dysfunction and pelvic floor abnormalities. The use of 3D\u2010HD ARM may enhance TASR detection, suggesting a potential role in FI pathophysiology. Further studies are needed to determine its clinical significance and impact on treatment response, particularly regarding biofeedback therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70125","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T07:22:13Z","timestamp":1752736933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transient Anal Sphincter Relaxations in Fecal Incontinence: Insights From <scp>3D<\/scp> High\u2010Definition Anorectal Manometry"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-3741","authenticated-orcid":false,"given":"Francisco Alejandro","family":"Felix\u2010Tellez","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal Instituto de Investigaciones M\u00e8dico\u2010Biol\u00f3gicas, Universidad Veracruzana  Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-6291","authenticated-orcid":false,"given":"Ra\u00fal Alberto","family":"Jim\u00e9nez\u2010Castillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal Instituto de Investigaciones M\u00e8dico\u2010Biol\u00f3gicas, Universidad Veracruzana  Veracruz Veracruz Mexico"},{"name":"Gastroenterology and Endoscopy Service \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital, Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Amieva\u2010Balmori","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal Instituto de Investigaciones M\u00e8dico\u2010Biol\u00f3gicas, Universidad Veracruzana  Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Roc\u00edo","family":"Garc\u00eda\u2010Zerme\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal Instituto de Investigaciones M\u00e8dico\u2010Biol\u00f3gicas, Universidad Veracruzana  Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-9659","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Remes\u2010Troche","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal Instituto de Investigaciones M\u00e8dico\u2010Biol\u00f3gicas, Universidad Veracruzana  Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.396"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.09.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101272825"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2024.1340720"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2.3.323"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15168"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13530"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19129"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20142"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.12.034"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(17)30428-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00496147"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800250"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02050996"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010199610000\u201000014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14810"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14335"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2021.20430"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13049"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:04:43Z","timestamp":1760760283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/nmo.70125"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70125","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70125"}}