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Accordingly, we developed a novel, 9\u2010week, phone\u2010delivered BGBT to cultivate PPWB in IBS, and examined its feasibility, acceptability, and preliminary effects in a randomized waitlist\u2010controlled proof\u2010of\u2010concept trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two adults with IBS meeting Rome IV criteria were randomized, stratified by gender and IBS subtype, to the intervention (<jats:italic>n<\/jats:italic>\u2009=\u200912) or waitlist\u2010control (WLC; <jats:italic>n<\/jats:italic>\u2009=\u200910) groups. Participants completed specific positive psychology (PP) activities and phone sessions weekly with an interventionist. Intervention feasibility was assessed by the proportion of completed sessions, and acceptability by weekly ease\/utility ratings. Exploratory psychological and health\u2010related self\u2010report measures were collected pre\u2010 and post\u2010intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Participants (<jats:italic>N<\/jats:italic>\u2009=\u200922; ages 19\u201379; 55% female) completed 85% of sessions, above our a priori feasibility threshold of 65%. The intervention was rated as easy to complete (mean\u2009=\u20097.2\/10, 95% CI: [6.70, 7.75]) and subjectively helpful (mean\u2009=\u20097.6\/10, 95% CI: [7.14, 8.01]). Of the 18 participants who completed the intervention, 11 (61%) no longer met criteria for IBS post\u2010intervention. Compared to the WLC, the intervention led to promising but nonsignificant improvements in exploratory clinical outcomes including IBS symptom severity, IBS health\u2010related quality of life, and resilience, with effect sizes ranging from 0.1 to 0.7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>This 9\u2010week, phone\u2010delivered intervention targeting greater PPWB in IBS was feasible, well\u2010accepted, and associated with promising improvements in key IBS\u2010related outcomes, highlighting the need for further testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70146","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:22:50Z","timestamp":1756102970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Randomized Waitlist\u2010Controlled Trial of a Positive Psychology Intervention for Irritable Bowel Syndrome: The WISH Proof\u2010of\u2010Concept Trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Elizabeth N.","family":"Madva","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Neurointestinal Health, Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff C.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Harnedy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesiya","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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