{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:09:34Z","timestamp":1760832574739,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carbonated water has long been a popular beverage, but its impact on esophageal motility remains unclear. This study aimed to evaluate the effect of carbonated water using high\u2010resolution esophageal manometry (HRM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A standard HRM protocol, incorporating measurements in both supine and upright positions per the updated Chicago Classification v4.0, along with additional carbonated water swallows, was performed in our motility laboratory. Ineffective esophageal motility (IEM) was diagnosed based on &gt;\u200970% ineffective swallows or \u2265\u200950% failed peristalsis in the supine position and categorized as \u201cSupine IEM (SI)\u201d. Patients who met the IEM diagnostic criteria in the upright position but not in the supine position were classified as \u201cUpright Ineffective (UI)\u201d for further comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 62 patients were found to have ineffective motility, with 30 diagnosed with IEM (SI group) and 32 categorized as UI. Compared with the standard water swallows, carbonated water increased the median DCI in the upright position (130 vs. 208\u2009mmHg\u00b7cm\u00b7s, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). It also reduced the proportion of failed peristalsis (85% vs. 65%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and ineffective swallows (94% vs. 69%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) during upright swallows. The number of ineffective motility cases was reduced from 30 to 26 in the SI group, indicating a 13% improvement, and from 32 to 22 in the UI group, representing a 31% improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Carbonated water significantly improves esophageal motility, particularly in the upright position. This effect is more pronounced in patients with upright ineffective motility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70149","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:22:09Z","timestamp":1756102929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Carbonated Water on Esophageal Motility in Different Body Positions: A Study Based on High\u2010Resolution Manometry"],"prefix":"10.1111","volume":"37","author":[{"given":"Kun\u2010Ching","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-7538","authenticated-orcid":false,"given":"Ping\u2010Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Division of Endoscopy, Department of Integrated Diagnostic &amp; Therapeutics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu\u2010Heng","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Lung","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siou\u2010Ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200209000-00010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(86)80034-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12204"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-021-00849-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9779-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-019-0728-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14593"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13584"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.11.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111320"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01273.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:04:43Z","timestamp":1760760283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/nmo.70149"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70149","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2025,8,24]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70149"}}