{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:10:05Z","timestamp":1760832605543,"version":"build-2065373602"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010450","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reduction of intestinal glucose absorption plays a key role in the antidiabetic action of certain antihyperglycemic agents. This study assesses the impact of the myrtle berry seeds aqueous (MBSAE) in managing diabetes and its related complications, placing particular emphasis on its ability to block glucose absorption across the jejunal epithelium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Ussing chamber system, we assessed the effect of <jats:styled-content style=\"fixed-case\">MBSAE<\/jats:styled-content> on electrogenic glucose transport across the mice jejunal epithelium. To complement these ex\u00a0vivo findings, we used an alloxan\u2010induced diabetic rat model to evaluate the extract's systemic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The extract significantly reduced glucose\u2010induced short\u2010circuit currents, suggesting a direct inhibitory effect on intestinal glucose absorption, potentially via <jats:styled-content style=\"fixed-case\">SGLT1<\/jats:styled-content> modulation. Therefore, <jats:styled-content style=\"fixed-case\">MBSAE<\/jats:styled-content> treatment significantly reduced plasma glucose and improved lipid profiles, hepatic and renal function, as well as hematological markers. It also helped restore antioxidant defenses by increasing <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">GPx<\/jats:styled-content> activities, as well as <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> and thiol group levels, while reducing <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and reactive oxygen species in both liver and kidney tissues. Inflammatory markers like <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 were also lowered after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altogether, these results point toward a multi\u2010targeted antidiabetic action of <jats:styled-content style=\"fixed-case\">MBSAE<\/jats:styled-content>. By limiting intestinal glucose absorption, the extract may help to reduce postprandial glycemic excursions and offer a novel gut\u2010targeted approach to diabetes management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70154","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:51:45Z","timestamp":1757667105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Jejunal Glucose Absorption as a Central Mechanism in the Antidiabetic Action of Myrtle Berry Seeds Aqueous Extract"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5283-917X","authenticated-orcid":false,"given":"Soumaya","family":"Hajaji","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Ressources\u2014Higher Institute of Biotechnology of Beja University of Jendouba  Jendouba 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