{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:31:54Z","timestamp":1793417514040,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with IBS often report meal\u2010related symptoms, which may negatively affect IBS\u2010related quality of life, psychological health, and lead to food\u2010avoidant behaviors. However, the understanding of the epidemiology of these symptoms is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared characteristics of adult patients with Rome IV\u2010defined IBS with and without meal\u2010related abdominal discomfort or pain \u2265\u200950% of the time. Participants were recruited from the ContactME\u2010IBS research register. We collected data concerning demographics, IBS symptoms, psychological health, quality of life, and impact on work and daily activities\u2009using validated questionnaires. We used logistic regression to explore independent predictors of meal\u2010related discomfort or pain \u2265\u200950% of the time in IBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Of 752 respondents with Rome IV IBS, 561 (74.6%) reported meal\u2010related abdominal discomfort or pain \u2265\u200950% of the time. 89.3% of individuals with meal\u2010related discomfort or pain \u2265\u200950% of the time were female vs. 80.6% of those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Those with meal\u2010related discomfort or pain \u2265\u200950% of the time were younger (43.7\u2009years vs. 50.1\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had a higher prevalence of symptoms meeting criteria for functional dyspepsia (FD), especially postprandial distress syndrome (49.1% vs. 30.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and reported higher gastrointestinal symptom\u2010specific anxiety scores, lower IBS\u2010related quality of life scores, and higher levels of activity impairment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all analyses). After logistic regression analysis, females, those meeting criteria for FD, younger individuals, and those reporting higher gastrointestinal symptom\u2010specific anxiety scores were more likely to report meal\u2010related discomfort or pain \u2265\u200950% of the time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Meal\u2010related abdominal discomfort or pain \u2265\u200950% of the time was associated with female sex, younger age, and comorbid FD. Better characterization and recognition of patients affected by meal\u2010related discomfort or pain may allow more personalized dietary and psychological interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70174","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:24:29Z","timestamp":1759217069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiology of Meal\u2010Related Abdominal Discomfort or Pain in Irritable Bowel Syndrome"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0136-6112","authenticated-orcid":false,"given":"Melanie S.","family":"Cuffe","sequence":"first","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek C.","family":"Goodoory","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-9165","authenticated-orcid":false,"given":"Cho Ee","family":"Ng","sequence":"additional","affiliation":[{"name":"County Durham and Darlington NHS Foundation Trust  Durham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-3603","authenticated-orcid":false,"given":"Christopher J.","family":"Black","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander 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