{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:31:25Z","timestamp":1793349085811,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic gastrointestinal diseases (EGIDs) are chronic, immune\u2010mediated diseases characterized by pathological infiltration of eosinophils in the gut. EGIDs include eosinophilic esophagitis (EoE), gastritis (EoG), enteritis (EoN), and colitis (EoC). There are no approved drugs for non\u2010EoE EGIDs due to a lack of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Methods<\/jats:title>\n                    <jats:p>In this case series, we report the efficacy of dupilumab\u2014prescribed for concomitant EoE\u2014for the induction and maintenance of remission of non\u2010EoE EGIDs. Adult patients (&gt;\u200918\u2009years) diagnosed with non\u2010EoE EGIDs and concomitant EoE who had been prescribed dupilumab 300\u2009mg weekly were prospectively enrolled. Outcome assessment was performed according to EGID\u2010specific instruments when available (i.e., peak eosinophil count, modified dysphagia questionnaire, Pisa EoE adaptation questionnaire, EoE and EoG endoscopic reference scores).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four patients were included. All were female and their age spanned 21\u201377\u2009years at diagnosis. Two patients had EoE\u2009+\u2009EoG (case 1 and 2), one EoE\u2009+\u2009EoG\u2009+\u2009EoN (case 3), and one EoE\u2009+\u2009EoN\u2009+\u2009EoC (case 4). EoG presented with epigastric pain, while EoN and EoC presented with abdominal pain and diarrhea. Cases 1 and 2 achieved clinical, endoscopic, and histological remission with induction corticosteroid treatment, while case 3 did not, and case 4 developed steroid\u2010related adverse events. When switched to dupilumab 300\u2009mg weekly, cases 1, 2, and 3 achieved histological remission and sustained clinical remission up to 12\u201318\u2009months from induction. In case 4, dupilumab achieved histologic remission and partial clinical response up to 16\u2009months from induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dupilumab, prescribed for EoE, may be effective for the management of concomitant non\u2010EoE EGIDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70177","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T13:54:41Z","timestamp":1760795681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Dupilumab for Induction and Maintenance of Remission in Patients With Eosinophilic Gastritis, Enteritis, and Colitis With Concomitant Eosinophilic Esophagitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5301","authenticated-orcid":false,"given":"Pierfrancesco","family":"Visaggi","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Castagnaro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Cairoli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Testi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Mitilini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bellini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo V.","family":"Savarino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1060","authenticated-orcid":false,"given":"Nicola","family":"de Bortoli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.02.017"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"23","article-title":"Eosinophilic Esophagitis: Novel Concepts Regarding Pathogenesis and Clinical Manifestations","volume":"68","author":"Scium\u00e8 G. D.","year":"2022","journal-title":"Minerva Gastroenterol (Torino)"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.02.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329873"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.02.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003194"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015165"},{"key":"e_1_2_10_9_1","unstructured":"EMA \u201cDupilumab Approval EMA \u201d (2023) https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/dupixent\u2010epar\u2010product\u2010information_en.pdf."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.05.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.10.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003272"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S276869"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000646"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000001187"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000908"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.70177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:50:20Z","timestamp":1793346620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/nmo.70177"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70177","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}