{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:31:37Z","timestamp":1787643097441,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Functional lumen imaging probe (\n FLIP<\/jats:styled-content>\n ) panometry assesses esophageal motility during sedated endoscopy. Recently, the\n FLIP<\/jats:styled-content>\n panometry motility classification was refined (v2.0) in the Dallas Consensus. This study aimed to characterize esophageal motility using the\n FLIP<\/jats:styled-content>\n v2.0 classification scheme and compare its classifications with those of\n FLIP<\/jats:styled-content>\n v1.0 and high\u2010resolution manometry (\n HRM<\/jats:styled-content>\n ) diagnoses on the basis of Chicago Classification v4.0 (\n CCv4<\/jats:styled-content>\n .0).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 805 adult patients who completed both\n FLIP<\/jats:styled-content>\n and\n HRM<\/jats:styled-content>\n at two tertiary esophageal centers were included; 704 with conclusive\n CCv4<\/jats:styled-content>\n .0 diagnoses comprised the primary analysis, and 101 with inconclusive\n CCv4<\/jats:styled-content>\n .0 diagnoses were also described. Esophagogastric junction (\n EGJ<\/jats:styled-content>\n ) opening and contractile response (\n CR<\/jats:styled-content>\n ) patterns were evaluated using 16\u2010cm\n FLIP<\/jats:styled-content>\n during sedated endoscopy, with motility classifications defined by\n FLIP<\/jats:styled-content>\n v1.0 and v2.0 criteria.\n HRM<\/jats:styled-content>\n was classified per\n CCv4<\/jats:styled-content>\n .0.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the primary analysis, among the 137 (19%) patients with normal motility on\n FLIP<\/jats:styled-content>\n panometry, 93% had normal motility or ineffective esophageal motility (\n IEM<\/jats:styled-content>\n ) on\n HRM<\/jats:styled-content>\n . Normal motility on\n FLIP<\/jats:styled-content>\n panometry had a 99% negative predictive value for disorders of\n EGJ<\/jats:styled-content>\n outflow. Among the 163 (23%) patients with non\u2010spastic obstruction (defined by reduced\n EGJ<\/jats:styled-content>\n opening and absent\/diminished\n CR<\/jats:styled-content>\n ) on\n FLIP<\/jats:styled-content>\n panometry, 91% had a conclusive disorder of\n EGJ<\/jats:styled-content>\n outflow on\n HRM<\/jats:styled-content>\n . Among the 37 patients with type\n III<\/jats:styled-content>\n achalasia on\n HRM<\/jats:styled-content>\n , 16 (43%) were classified as spastic obstruction on\n FLIP<\/jats:styled-content>\n panometry.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n FLIP<\/jats:styled-content>\n panometry v2.0 categorized esophageal motility in a manner that frequently paralleled the\n HRM<\/jats:styled-content>\n \/\n CCv4<\/jats:styled-content>\n .0 diagnoses.\n FLIP<\/jats:styled-content>\n panometry offers a well\u2010tolerated approach that complements, or may be an alternative to,\n HRM<\/jats:styled-content>\n for diagnosing esophageal motility disorders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.70188","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:16:17Z","timestamp":1761192977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of Functional Lumen Imaging Probe Panometry Esophageal Motility Classification Version 2.0: A Study of 805 Patients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-6192","authenticated-orcid":false,"given":"Ofer Z.","family":"Fass","sequence":"first","affiliation":[{"name":"Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaston","family":"Becherano","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-2070","authenticated-orcid":false,"given":"Wenjun","family":"Kou","sequence":"additional","affiliation":[{"name":"Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton C.","family":"Ellison","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanakyaram A.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Spechler","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vani J. A.","family":"Konda","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Center for Esophageal Diseases, Division of Gastroenterology Baylor University Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"Dustin A.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12572"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.454"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.06.039"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001532"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.01.234"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14116"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.07.042"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.09.032"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14981"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.06.040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14192"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14182"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14193"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.2.9242756"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.370"},{"key":"e_1_2_10_19_1","unstructured":"R Core Team \u201cR: A Language and Environment for Statistical Computing \u201d(2023) https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.052"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14818"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14449"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14552"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14729"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2025.03.1329"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T12:48:58Z","timestamp":1764506938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/nmo.70188"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70188","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"2025-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70188"}}