{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T12:51:17Z","timestamp":1764507077567,"version":"3.46.0"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Arbutus and hawthorn fruits are commonly utilized in traditional medicine to address various gastrointestinal (\n GI<\/jats:styled-content>\n ) ailments. Our primary aim was to individually assess the effects of aqueous extracts from\n \n Arbutus unedo<\/jats:italic>\n <\/jats:styled-content>\n (\n AUAE<\/jats:styled-content>\n ) and\n \n Crataegus monogyna<\/jats:italic>\n <\/jats:styled-content>\n (\n CMAE<\/jats:styled-content>\n ) fruits on\n GI<\/jats:styled-content>\n motility, spontaneous jejunal smooth muscle contractility, and hyperglycemia management.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Wistar rats were administered loperamide (\n LOP<\/jats:styled-content>\n , 3\u2009mg\/kg, b.w.) along with\n AUAE<\/jats:styled-content>\n or\n CMAE<\/jats:styled-content>\n (at doses of 75, 150 and 300\u2009mg\/kg, b.w.) or yohimbine (\n YOH<\/jats:styled-content>\n , 2\u2009mg\/kg, b.w.).\n GI<\/jats:styled-content>\n transit was evaluated using the charcoal meal test. The impact of both extracts on jejunal secretion and contraction was assessed using the Ussing chamber technique and the isometric transducer. The bioactive constituents of\n AUAE<\/jats:styled-content>\n and\n CMAE<\/jats:styled-content>\n were analyzed via liquid chromatography\u2010high resolution electrospray ionization mass spectrometry (\n LC<\/jats:styled-content>\n \u2010\n HRESIMS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AUAE<\/jats:styled-content>\n and\n CMAE<\/jats:styled-content>\n comprise bioactive compounds, including phenolic acids, flavonoids, and flavonols, capable of eliciting various intended physiological effects. Both extracts demonstrated a significant and dose\u2010dependent increase in\n GI<\/jats:styled-content>\n transit (77.33%\u201389.83% and 80.31%\u201385.54%, respectively) compared to the delayed peristalsis induced by\n LOP<\/jats:styled-content>\n (42.77%) and the accelerated effect of\n YOH<\/jats:styled-content>\n (90.09%). Both extracts induced an increase in the amplitude of spontaneous jejunal contraction with an\n \n EC\n 50<\/jats:sub>\n <\/jats:styled-content>\n of 90.47 and 22.98\u2009\u03bcg\/\n mL<\/jats:styled-content>\n , respectively. Conversely, the two extracts did not impact the electrogenic transport of intestinal fluid when compared to the action produced by forskolin (\n FSK<\/jats:styled-content>\n , 10\u2009\n \u03bcM<\/jats:styled-content>\n ). Additionally, both extracts significantly reduced glucose levels in hyperglycemic rats compared to control values.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings hold promise for the development of novel preventive and pharmacological treatment strategies for\n GI<\/jats:styled-content>\n disorders and diabetes management.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.70189","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:32:01Z","timestamp":1761625921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Wild Edible Fruits of\n \n Arbutus unedo<\/i>\n <\/scp>\n and\n \n Crataegus monogyna<\/i>\n <\/scp>\n on Gut Motility, Contraction, Secretion, and Glucose Regulation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8475-7854","authenticated-orcid":false,"given":"Soumaya","family":"Wahabi","sequence":"first","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja LR: Functional Physiology and Valorization of Bio\u2010Resources Beja Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kais","family":"Rtibi","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja LR: Functional Physiology and Valorization of Bio\u2010Resources Beja Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaima","family":"Abidi","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja LR: Functional Physiology and Valorization of Bio\u2010Resources Beja Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Jridi","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja LR: Functional Physiology and Valorization of Bio\u2010Resources Beja Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Gressier","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, UFR3S, Dept of Pharmacy University of Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-1401","authenticated-orcid":false,"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja LR: Functional Physiology and Valorization of Bio\u2010Resources Beja 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