{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:51:54Z","timestamp":1778554314359,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>5\u2010HT3 receptor antagonists, such as ondansetron, are effective in the management of irritable bowel syndrome\u2010diarrhea predominant (IBS\u2010D). However, real\u2010world data and evidence exploring the response to ondansetron in patients with functional diarrhea (FDr) are lacking. The aim of this study was to assess the clinical characteristics and response to ondansetron among patients with bowel disorders associated with chronic diarrhea in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We conducted a retrospective study of consecutive patients (October 2016\u2013February 2024) diagnosed with IBS\u2010D or FDr in a tertiary care neurogastroenterology outpatient clinic. Demographic, clinical data, previous surgery, relevant investigations and current medications were collected. Clinical response to ondansetron was defined as (i) a reduction of at least one bowel movement\/day versus baseline and (ii) firmer stool consistency (an improvement of \u2265\u20091 on the Bristol Stool Form Scale [BSFS] vs. baseline).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010two patients were included, among whom 75 (81%) and 17 (18%) had IBS\u2010D and FDr, respectively. Urgency to defecate was significantly more frequent in patients with FDr versus IBS\u2010D (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Sixty\u2010eight of the 92 patients (73.9%) reported a clinical response to ondansetron, which was maintained at a median dosage of 8\u2009mg\/day for a median duration of 19\u2009months with few minor side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When used in clinical practice, 8\u2009mg\/day of ondansetron is associated with a reduction in bowel frequency and an improvement in fecal consistency in approximately two\u2010thirds of patients with IBS\u2010D and FDr.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70193","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:00:09Z","timestamp":1762142409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Outcomes of Rome\n                    <scp>IV<\/scp>\n                    Diarrhea\u2010Predominant Irritable Bowel Syndrome and Functional Diarrhea Prescribed With Ondansetron: A Real\u2010World Study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9267-9471","authenticated-orcid":false,"given":"Caterina","family":"Sbarigia","sequence":"first","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"},{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sant'Andrea Hospital, Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lambiase","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"},{"name":"Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsin F.","family":"Butt","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulsalam I.","family":"Aliyu","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4500","authenticated-orcid":false,"given":"Robin","family":"Spiller","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4684","authenticated-orcid":false,"given":"Maura","family":"Corsetti","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Centre, School of Medicine University of Nottingham  Nottinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12259"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505180"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.11.015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010324598"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010327293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17426"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.14.1733"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802240255"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010318160"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.70007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.15019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.421"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13738"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00023\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010305989"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000727"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.34172\/mejdd.2024.386"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00459.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T12:48:06Z","timestamp":1764506886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,2]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/nmo.70193"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70193","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,2]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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