{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:03:25Z","timestamp":1790877805578,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disorders of gut\u2010brain interaction (DGBI) are associated with reduced health\u2010related quality of life (HRQoL) and psychological disorders. Among individuals with DGBI, abdominal pain correlates with increased healthcare\u2010seeking and analgesic use. This study aimed to evaluate the influence of pain as a cardinal symptom on HRQoL and psychological disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a sub\u2010analysis of data from four Latin American countries included in the Rome Foundation Global Epidemiology Study (RFGES). DGBI were classified into (1) painful DGBI, including individuals with diagnoses characterized by pain as a primary symptom, and (2) non\u2010painful DGBI, including individuals with only non\u2010painful diagnoses. Prevalence rates, healthcare\u2010seeking behavior, HRQoL (Patient\u2010Reported Outcomes Measurement Information System Global\u201010 [PROMIS Global\u201010]), anxiety and depression (Patient Health Questionnaire\u20104 [PHQ\u20104]) and somatization (Patient Health Questionnaire\u201012 [PHQ\u201012]) were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>A total of 8069 participants from the four countries completed the RFGES online survey, including 1132 in the painful group and 1720 in the non\u2010painful group. Participants with painful DGBI more commonly sought healthcare at least monthly compared to those with non\u2010painful disorders (18.6% vs. 14.9%). Painful disorders were associated with significantly lower HRQoL scores and higher PHQ\u20104 and PHQ\u201012 scores, both in unadjusted and adjusted analyses (sex, age, education, and community size).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Inferences<\/jats:title>\n                    <jats:p>In four Latin American countries, individuals with painful DGBI were more likely to seek healthcare, had worse HRQoL and exhibited greater psychological distress compared to those with non\u2010painful DGBI. These findings highlight the need for targeted interventions for individuals with painful DGBI symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70194","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:36:42Z","timestamp":1762832202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Painful Disorders of Gut\u2010Brain Interaction Are More Associated With Worse Health\u2010Related Quality of Life and Psychological Disorders Than Non\u2010Painful Disorders in Latin American Countries"],"prefix":"10.1111","volume":"37","author":[{"given":"R\u00f4mulo","family":"Marx","sequence":"first","affiliation":[{"name":"Gastroenterology Division, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal Do Rio Grande Do Sul  Porto Alegre Brazil"},{"name":"Graduate Program: Sciences in Gastroenterology and Hepatology, School of Medicine Universidade Federal do 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