{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:11:53Z","timestamp":1769699513906,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A significant, yet often overlooked, complication of subarachnoid hemorrhage (SAH) is the development of acidosis. Denervation atrophy is a recognized cause of neural ganglion damage following primary motor neuron damage, but the effect of tissue pH changes has not been thoroughly investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigates whether acidosis causes Auerbach ganglia damage following SAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four hybrid rabbits were selected, and five (GI;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) were used for the analysis of the Auerbach ganglia. Six animals (GII;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) were allocated to the SHAM group, receiving 1\u2009cc of saline. The remaining 13 animals (GIII;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) were allocated to the study group, receiving 1\u2009cc of autologous arterial blood injected into the cisterna magna to induce subarachnoid hemorrhage under general anesthesia. Blood pH values were recorded before the experiment, on the seventh day, and immediately before sacrifice. Animals were sacrificed after 1\u2009week, and the degenerated neuron density of the Auerbach ganglia in 1\u2009cm segments of the ascending colon was estimated. The pH values and degenerated Auerbach ganglia neuron densities (n\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) were compared using the Mann\u2013Whitney U test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The presurgical blood pH values of all animals were 7.431\u2009\u00b1\u20090.032. On the seventh day, pH values were 7.403\u2009\u00b1\u20090.052 in GI; 7.395\u2009\u00b1\u20090.024 in GII; and 7.264\u2009\u00b1\u20090.045 in GIII. At the end of the experiment, pH values were 7.431\u2009\u00b1\u20090.037 in GI; 7.395\u2009\u00b1\u20090.062 in GII; and 7.330\u2009\u00b1\u20090.035 in GIII. Degenerated neuron densities of Auerbach ganglia neurons were 13\u2009\u00b1\u20094 in GI, 34\u2009\u00b1\u20096 in the SHAM group, and 87\u2009\u00b1\u200915 in GIII. The\n                      <jats:italic>p<\/jats:italic>\n                      values were:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005 for GII\/GI;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 for GII\/GIII; and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00005 for GI\/GIII.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acidosis is a potential causative factor of Auerbach ganglia degeneration following SAH, a phenomenon not previously described.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70214","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T19:45:13Z","timestamp":1765136713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The First Description of Auerbach Ganglia Injury by Acidic Blood Following Subarachnoid Hemorrhage: An Experimental Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-1252","authenticated-orcid":false,"given":"Enes","family":"A\u011f\u0131rman","sequence":"first","affiliation":[{"name":"Department of General Surgery Erzurum City Hospital  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-5254","authenticated-orcid":false,"given":"R\u0131fat","family":"Peks\u00f6z","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-3675","authenticated-orcid":false,"given":"Furkan Ali","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine Giresun University  Giresun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7480-6769","authenticated-orcid":false,"given":"Muhammet","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of General Surgery Erzurum City Hospital  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-6461","authenticated-orcid":false,"given":"Sabri Sel\u00e7uk","family":"Atamanalp","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-9739","authenticated-orcid":false,"given":"Mehmet Dumlu","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"19","article-title":"Iatrogenic Ejaculation Disorders and Their Prevention","volume":"53","author":"Terrone C.","year":"2001","journal-title":"Minerva Urologica e Nefrologica"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.01.082"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2017.1412961"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101838(95)00125\u20105"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1634069"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fdabba"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(86)90005\u20104"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"65","article-title":"Uber Die in der Dickdarmwand Aszendierenden Nerven Des Plexus Pelvinus Und Die Grenze der Vagalen Und Sakralparasympathischen Innervation [Ascending Nerves of the Plexus Pelvinus of the Wall of the Large Intestine and the Limits of Vagal and Sacral Parasympathetic Innervation]","volume":"84","author":"Stach W.","year":"1971","journal-title":"Zeitschrift f\u00fcr Mikroskopisch\u2010Anatomische Forschung"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.1962.tb01187.x"},{"issue":"3","key":"e_1_2_13_11_1","first-page":"60P","article-title":"An In\u00a0Vitro Preparation of the Distal Colon of the Rabbit With Orthosympathetic and Parasympathetic Innervation","volume":"123","author":"Garry R. 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