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DGBI encompass a range of gastrointestinal symptoms in the absence of identifiable structural etiologies with biopsychosocial implications. Ongoing research efforts aim to understand the etiology and pathophysiology of DGBI, with disruptions of the gut\u2010brain axis leading to visceral hypersensitivity and hypervigilance believed to be involved in symptom manifestation. Currently, there are 17 pediatric DGBI that are diagnosed via the Rome IV criteria. However, there is a paucity of research evaluating the clinical presentation, diagnosis, and management of pediatric patients with DGBI and concurrent structural gastrointestinal conditions despite the significant symptom overlap and diagnostic challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This summative review will aid clinicians by providing an updated overview of pediatric studies assessing the overlap between DGBI and inflammatory bowel disease, celiac disease, and eosinophilic gastrointestinal disorders. Functional abdominal pain, irritable bowel syndrome, and functional constipation are common DGBI subtypes in pediatric patients with underlying structural gastrointestinal disorders. It is imperative that clinicians be cognizant of this overlap, particularly when gastrointestinal symptoms persist despite appropriate management of structural conditions. In such cases, a multidisciplinary approach may be necessary if there is concern for a comorbid DGBI to provide comprehensive care for patients and to improve quality of life, provider satisfaction, and successful clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70231","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:21:08Z","timestamp":1768839668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut\u2010Brain Interaction"],"prefix":"10.1111","volume":"38","author":[{"given":"Andrew","family":"Krueger","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umber","family":"Waheed","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-079X","authenticated-orcid":false,"given":"Neha","family":"Santucci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.017"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_14_4_1","volume-title":"Rome IV Criteria","year":"2021"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001023"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.012"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002610\u20106"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.08.022"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002751"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.12.009"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.042"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395\u2010018\u20100262\u2010x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889\u20108553(05)70064\u20109"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21349"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz182"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010058037"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001216"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010006\u20100013\u20108"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400413"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy015"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12188"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jss097"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182802a0a"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.02.011"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000841"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000850"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001479"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.05.034"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12791"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000001077"},{"key":"e_1_2_14_34_1","doi-asserted-by":"crossref","unstructured":"N. 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