{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:07:39Z","timestamp":1769699259276,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathophysiology of rumination syndrome is not entirely elucidated. We aimed to assess gastric emptying and fundic accommodation through solid gastric emptying scintigraphy in children with rumination syndrome and explore the relationship between scintigraphic findings and high\u2010resolution impedance esophageal manometry results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Gastric retention at 1, 2, 3, and 4\u2009h from standardized meal ingestion were measured. Delayed gastric emptying was defined as gastric retention &gt;\u200910% at 4\u2009h. The ratio of gastric counts in the proximal stomach to those in the entire stomach measured immediately after meal ingestion (IMD\n                      <jats:sup>0<\/jats:sup>\n                      ) was used as a marker of fundic accommodation. A value of &lt;\u20090.568 defined an impaired fundic accommodation. The number of rumination episodes occurring during the first postprandial hour of manometry recording were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 33 children included (median age: 14\u2009years) 10 (30%) had impaired fundic accommodation and 12 (36%) delayed gastric emptying. Children with impaired fundic accommodation have a higher median number of rumination events [10 (IQR 7\u201312) vs. 6 (IQR 4\u201389);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03] recorded during the first postprandial hour. Similarly, at 1\u2010h children with delayed gastric emptying have a higher median number of rumination events [12 (IQR 10\u201313) vs. 6 (IQR 3\u20138);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004]. The number of rumination events was inversely related to IMD\n                      <jats:sup>0<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.4) and directly related to gastric retention at 1\u2010h in the whole stomach (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.5), fundus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.4) and antrum (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than half of children with rumination syndrome included in our study present an abnormal gastric motor function on solid\u2010meal gastric emptying scintigraphy that might contribute to the occurrence of rumination episodes. The detection of these abnormalities might enhance targeted clinical trials and patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70239","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:02:36Z","timestamp":1768834956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Gastric Motor Abnormalities in Pathophysiology of Rumination Syndrome in Children"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-4362","authenticated-orcid":false,"given":"Maria Giovanna","family":"Puoti","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London UK"},{"name":"Department of Paediatric Gastroenterology and Hepatology Santobono\u2010Pausilipon Children's Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina Chiara","family":"Pascuzzi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Biassoni","sequence":"additional","affiliation":[{"name":"Department of Radiology Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Radiology Great Ormond Street Hospital for Children  London UK"},{"name":"Department of Clinical Physics Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Lindley","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Pescarin","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornilia","family":"Nikaki","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rybak","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility Great Ormond Street Hospital for Children  London 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