{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:07:00Z","timestamp":1780063620148,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While some patients report full thickness rectal prolapse (RP) exclusively during defecation, others may experience it spontaneously during walking, exercise, and\/or all the time. We hypothesized that patients with RP only during defecation have more preserved physiological and anatomical characteristics and aimed to identify the phenotypes of patients with various RP expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of a prospectively maintained registry of women with RP (2017\u20132023) included clinical characteristics, MRI defecography (MRD), and high\u2010resolution anorectal manometry (HR\u2010ARM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Of 297 patients, 147 (49%) experienced defecation\u2010only RP, while 150 (51%) had spontaneous RP. The defecation\u2010only RP group was younger (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and exhibited higher obstructive defecation syndrome (ODS) scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), associated with higher rectal pressures at simulated defecation. The spontaneous RP patients had higher Wexner fecal incontinence scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and were more likely to seek medical care within 6\u2009months of symptom onset (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). On MRD, they had larger levator hiatus length, width, and bowl volume along with a wider anorectal angle. HR\u2010ARM showed lower resting anal pressures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and less sustained squeeze pressures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) in this group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Defecation\u2010only RP appears to represent a distinct phenotype, potentially an early stage of RP, characterized by younger age, more severe obstructive symptoms, more preserved anal sphincter function, and less pelvic floor laxity. Future research should focus on risk factors for progression to more sustained RP and the potential benefits of early intervention in patients with defecation\u2010only RP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70265","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:01:03Z","timestamp":1771473663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Phenotypes of Full\u2010Thickness Rectal Prolapse in Women: A Comparison of Defecation\u2010Only and Spontaneous Presentations"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-9512","authenticated-orcid":false,"given":"Zeyi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Surgery Stanford University School of Medicine  Stanford California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-5012","authenticated-orcid":false,"given":"Leila","family":"Neshatian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California 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