{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:07:13Z","timestamp":1780063633136,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H00360"],"award-info":[{"award-number":["23H00360"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24KJ1212"],"award-info":[{"award-number":["24KJ1212"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colonic inflammation is known to cause intestinal dysmotility. We examined the possible involvement of descending monoaminergic neurons projecting to the lumbosacral spinal cord in colorectal dysmotility using a rat model of colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Colitis was induced in rats by intracolonic administration of 2,4,6\u2010trinitrobenzenesulfonic acid. Motility in inflamed and noninflamed colorectal regions was assessed in\u00a0vivo under anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Colonic inflammation suppressed colorectal motility responses to noxious stimulus applied on inflamed colonic regions. The suppressed responses recovered as inflammation improved. In a subset of rats with colitis, basal motility in noninflamed regions was significantly enhanced, and this was abolished by intrathecal administration of serotonergic and dopaminergic receptor antagonists to the lumbosacral spinal cord. In some rats, enhanced basal motility spontaneously subsided then returned to a hyperactive state. The re\u2010enhanced basal motility was also suppressed by monoaminergic receptor antagonists, suggesting intermittent activity of the descending monoaminergic neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>This study suggested that persistent noxious input from an inflamed colon activates descending monoaminergic neurons, leading to enhanced basal motility in noninflamed regions. Our findings provide important insights into the pathophysiology of inflammation\u2010associated dysmotility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70277","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:07:33Z","timestamp":1772960853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Possible Involvement of Descending Monoaminergic Pathways in Colorectal Dysmotility Using a Rat Model of Colitis"],"prefix":"10.1111","volume":"38","author":[{"given":"Natsufu","family":"Yuki","sequence":"first","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences Gifu University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuno","family":"Hiroki","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of 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