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This study explores how electroacupuncture (EA) affects inflammation and damage to the colonic mucosa barrier in T2DM rats, and whether EA modulates EGCs activation through the Wnt\/\u03b2\u2010catenin\/NF\u2010\u03baB signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four rats' groups were used: Con, T2DM, EA, and EA\u2009+\u2009LGK974 (a Wnt\/\u03b2\u2010catenin inhibitor). Animal models in T2DM were triggered through diets heavy in fat, sugar, and streptozotocin (STZ) administration. Pishu (BL20), Tianshu (ST25), and Shangjuxu (ST37), and Weiwanxiashu (EX\u2010B3) all received 6\u2009weeks of EA. Tissue morphological, molecular, and metabolic alterations were evaluated by ELISA, H&amp;E staining, immunohistochemistry, Western Blotting, qPCR, immunostaining, and AB\u2010PAS staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Electroacupuncture (EA) suppressed the excessive activation of EGCs, upregulated expression of Wnt3a, p\u2010GSK3\u03b2, np\u2010\u03b2\u2010catenin, c\u2010Myc, and Cyclin D1 while downregulating NF\u2010\u03baB p65 and I\u03baB\u03b1 phosphorylation levels. Furthermore, EA reduced serum LPS levels, suppressed TNF\u2010\u03b1 and IL\u20106 levels, and enhanced tight junction protein expression. These effects were reversed by LGK974.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion &amp; Inferences<\/jats:title>\n                    <jats:p>Electroacupuncture (EA) ameliorates the integrity and functionality of the colonic mucosal barrier while mitigating inflammatory responses in T2DM by regulating excessive EGCs activation through activating the Wnt\/\u03b2\u2010catenin pathway, suppressing NF\u2010\u03baB signal transmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70295","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:25:26Z","timestamp":1775276726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electroacupuncture Ameliorates Colonic Mucosal Barrier Damage and Inflammation in\n                    <scp>T2DM<\/scp>\n                    Rats by Regulating Enteric Glial Cells Activation in Colon Through the Wnt\/\u03b2\u2010Catenin\/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway"],"prefix":"10.1111","volume":"38","author":[{"given":"Xiaolu","family":"Li","sequence":"first","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1010-6847","authenticated-orcid":false,"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-8762","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193001"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15010008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026\u20104806.18.05589\u20101"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1228938"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120261"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c03055"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010021\u201004086\u20105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.11.007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v15.i5.354"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2024.12774"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00378"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1535\u20106108(02)00154\u2010x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239199"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021294"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201005024\u2010y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.10.004"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65476"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121984"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010025\u201001683\u2010y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010024\u201001432\u20107"},{"key":"e_1_2_12_25_1","first-page":"135","article-title":"Electroacupuncture Improves Glucose Metabolism Through Modulation of Autonomic Nervous Activity in Diabetic Rats","volume":"706","author":"Liu Z.","year":"2019","journal-title":"Neuroscience Letters"},{"issue":"6","key":"e_1_2_12_26_1","first-page":"G718","article-title":"Electroacupuncture at Tianshu (ST25) Ameliorates Intestinal Barrier Dysfunction via the Vagal\u2010Immune Pathway in Rats","volume":"317","author":"Song J. 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