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While this association is discussed in the adult literature, this study aimed to examine the relations among ACEs, abdominal pain, and health\u2010related quality of life in children diagnosed with pain\u2010predominant disorders of gut\u2010brain interaction (DGBIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants consisted of 120 youth with a DGBI diagnosis involving chronic abdominal pain and their caregivers who responded to the Pediatric ACEs and Related Life Events Screener (PEARLS) tool. The PEARLS was organized by the following domains: Maltreatment (e.g., sexual, verbal, physical, and emotional abuse, and physical neglect), Household Challenges (e.g., caregiver mental or physical illness), and Social Context (e.g., housing and food insecurity). Child participants provided a retrospective 7 day rating of average abdominal pain intensity and completed the Pediatric Quality of Life Inventory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010two (60%) caregivers reported that their child had experienced maltreatment. In adjusted models, results revealed that maltreatment was significantly associated with a greater 7\u2010day average report of abdominal pain intensity (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05). Household challenges and social context were not significantly associated with abdominal pain intensity (both\n                      <jats:italic>p<\/jats:italic>\n                      's &gt;\u20090.05). Additionally, the experience of maltreatment was significantly associated with worse overall health\u2010related quality of life (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the profound impact that experiences of childhood maltreatment are likely to have on abdominal pain intensity and quality of life in pediatric patients with pain\u2010predominant DGBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70302","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:27:00Z","timestamp":1775557620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experience of Maltreatment Is Associated With Abdominal Pain Intensity and Health\u2010Related Quality of Life in Children With Pain\u2010Predominant Disorders of Gut\u2010Brain Interaction"],"prefix":"10.1111","volume":"38","author":[{"given":"Molly P.","family":"Barr","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology, &amp; Nutrition Washington University School of Medicine  St. Louis Missouri USA"},{"name":"SSM Health Cardinal Glennon Pediatrics Specialty Services  Edwardsville Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4601-0917","authenticated-orcid":false,"given":"Tolulope","family":"Adetayo","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne T.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily O.","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Division of Pain &amp; Palliative Medicine Connecticut Children's  Hartford Connecticut USA"},{"name":"Department of Pediatrics University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reed A.","family":"Dimmitt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology &amp; Hepatology University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"},{"name":"Dothan Pediatric Healthcare Network  Dothan Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-1310","authenticated-orcid":false,"given":"Burel R.","family":"Goodin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Washington 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