{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:29:39Z","timestamp":1784694579577,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with postural orthostatic tachycardia syndrome (POTS) frequently report higher rates of chronic gastrointestinal symptoms, disorders of gut\u2010brain interaction (DGBI), and extra\u2010intestinal co\u2010morbidities. We conducted a systematic review and meta\u2010analysis to assess the prevalence of gastrointestinal symptoms and comorbid conditions in POTS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic databases were searched from inception until May 2025 for studies reporting gastrointestinal symptoms in POTS patients. A random\u2010effects model was used to pool the proportion of POTS patients reporting gastrointestinal symptoms, and sub\u2010group analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The final dataset includes 19 studies, with 8268 POTS patients, revealing that 57.9% (95% CI 38.4\u201375.2) had at least one gastrointestinal symptom. The most common gastrointestinal symptom was nausea (70.1%, 95% CI 51.5\u201383.7) followed by bloating (64.9%, 95% CI 48.5\u201378.4), abdominal pain (60.4%, 95% CI 39.2\u201378.3) and postprandial fullness (60.4%, 95% CI 45.6\u201373.6). Irritable bowel syndrome was the most prevalent DGBI, affecting 26.8% (95% CI 15.3\u201342.4) of POTS patients. The most common extraintestinal comorbidity was anxiety, reported in 42.9% (95% CI 22.7\u201365.8), followed by chronic fatigue (40.9%, 95% CI 21.1\u201364.2), migraine (35.6%, 95% CI 27.0\u201345.2), depression (34.4%, 95% CI 19.0\u201354.0), and fibromyalgia (21.6%, 95% CI 12.8\u201334.2). Approximately one third reported mast cell activation syndrome (36.3%, 95% CI 17.8\u201360.0) and joint hypermobility syndrome (31%, 95% CI 24.4\u201338.5). There was substantial heterogeneity seen in the primary and most subgroup analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, 60% of POTS patients report concurrent gastrointestinal symptoms, with nausea being the most common. IBS affects 25% of patients with POTS. Notably, extra\u2010intestinal comorbidities\u2014primarily anxiety, chronic fatigue, migraines, depression, and fibromyalgia\u2014are more prevalent than gastrointestinal conditions in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70305","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:49:09Z","timestamp":1775706549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gastrointestinal Symptoms and Systemic Comorbidities in Patients With\n                    <scp>POTS<\/scp>\n                    : A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Dmitrii","family":"Kulin","sequence":"first","affiliation":[{"name":"Faculty of Medicine, The University of Queensland  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology &amp; 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