{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:26:42Z","timestamp":1784780802028,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Domperidone is used to treat refractory symptoms of gastroparesis. There is awareness about the risks and benefits of using domperidone; however, studies have primarily been short\u2010term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To review treatment results with domperidone with focus on long\u2010term efficacy and side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with gastroparesis symptoms who entered our FDA IND, IRB\u2010approved domperidone protocol between 2005 and 2025 were treated with oral domperidone 10\u2009mg 3\u20134 times daily and followed every 2\u2009months for the first year, then every 6\u2009months. Patients completed Patient Assessment of Upper GI Symptoms (PAGI\u2010SYM) and Clinical Patient Grading Assessment Scale (CPGAS; +3\u2009=\u2009great deal better, 0\u2009=\u2009no change).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>827 patients (64% idiopathic, 22% diabetic, 6% postsurgical, 5% atypical) participated; delayed gastric emptying in 86%, normal in 13%, and rapid in 1%. 298 patients have continued domperidone for 7.6\u2009\u00b1\u20096.4\u2009years with a dose of 36\u2009\u00b1\u200920\u2009mg per day. The CPGAS benefit score averaged 2.3\u2009\u00b1\u20090.9 (~\u201cmoderately better\u201d). There were improvements in symptoms, particularly nausea, postprandial fullness, and loss of appetite. 529 patients stopped domperidone treatment; lack of efficacy (114 patients), side effects (100), switching to another treatment (42), cost (26), and the remainder lost to follow up. Most common side effects for stopping DOM were palpitations (20 patients), prolonged EKG QTc (13), chest pain (11), diarrhea (10), headache (9), dizziness (8), and lactation (8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study of patients treated with long term domperidone for symptoms of gastroparesis, 298 of 827 (36%) patients continued treatment for a mean of 7.6\u2009years with patients reporting being moderately better. Thus, in select patients, domperidone treatment is an effective long\u2010term treatment for symptoms of gastroparesis, able to be safely administered with careful patient monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70309","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:08:37Z","timestamp":1775196517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Domperidone for Patients With Symptoms of Gastroparesis; Long\u2010Term Results"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Gastroenterology Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubair","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Gastroenterology Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Schey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Gastroenterology Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Gastroenterology Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.055"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001874"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.08.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1645594"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01255.x"},{"key":"e_1_2_10_8_1","first-page":"1230","article-title":"A Doubleblind Multicenter Comparison of Domperidone and Metoclopramide in the Treatment of Diabetic Patients With Symptoms of Gastroparesis","volume":"94","author":"Patterson D.","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_10_9_1","unstructured":"\u201cDomperidone FDA \u201dWeb Site http:\/\/www.fda.gov\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/investigationalnewdrugindapplication\/ucm368736.htm."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536840-000000000-00000"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4272-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00803-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08520-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-9567-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01612.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0124-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3097-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02076.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01636.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297028"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-0673.1996.00403.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2021-001968"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001183"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1472-2"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80054-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14652"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003534"}],"container-title":["Neurogastroenterology &amp; 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