{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:45:33Z","timestamp":1788561933125,"version":"build-2803163510"},"reference-count":135,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Visceral myopathy (VSCM) is an ultra\u2010rare life\u2010threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and uterine smooth muscle. This disorder represents a significant clinical challenge due to variable presentation and the lack of standardized diagnostic and therapeutic protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To discuss advances in the field, scientists and clinicians with a special interest in VSCM met in Arenzano, Genova, Italy in October 2024 for the second International Forum on Visceral Myopathy 2024 (IFVM2024) (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ifvm2024.ge.ibf.cnr.it\/\">https:\/\/ifvm2024.ge.ibf.cnr.it\/<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      As in the previous edition of the event (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/poic-e-dintorni.org\/efvm-2022\/\">https:\/\/poic\u2010e\u2010dintorni.org\/efvm\u20102022\/<\/jats:ext-link>\n                      ), attendees included clinicians and researchers from around the world who study this disease, representatives from support organizations, patients affected by VSCM and their families, and companies that co\u2010funded the event. The present manuscript aims to summarize knowledge shared during the IFVM2024 conference, thus providing an updated state\u2010of\u2010the\u2010art summary of VSCM biology and disease management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Here, we pay particular attention to the epidemiology of the disease, histopathology, genetics, novel treatments, advances in molecular and cell biology, experimental models, and the lived experiences and impact of this disorder on families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70317","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:34:43Z","timestamp":1776224083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease"],"prefix":"10.1111","volume":"38","author":[{"given":"Pascal","family":"de Santa Barbara","sequence":"first","affiliation":[{"name":"Physiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), University of Montpellier INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Ceccherini","sequence":"additional","affiliation":[{"name":"UOSD Aggregation Area of the Research Laboratories, IRCCS Giannina Gaslini Institute  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Heuckeroth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"The Children's Hospital of Philadelphia Research institute  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus University Medical Center\u2010Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Department of Pediatric Surgery Erasmus University Medical Center\u2010Sophia Children's Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Beyder","sequence":"additional","affiliation":[{"name":"Enteric Neuroscience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Physiology and Biomedical Engineering (BMEP) Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Neurogastroenterology &amp; Motility Unit, Department of Gastroenterology Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-9246","authenticated-orcid":false,"given":"Ludovica","family":"Cacopardo","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Research Center \u2018E. 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