{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:45Z","timestamp":1787068425086,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK125657"],"award-info":[{"award-number":["R01DK125657"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK131488"],"award-info":[{"award-number":["R01DK131488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK134689"],"award-info":[{"award-number":["R01DK134689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Many fecal incontinence (FI) patients have low anal sphincter pressure, which is thought to be a major pathophysiological mechanism. This is assessed either by stationary or pull\u2010through manometry techniques. Fecobionics is a new device for comprehensive assessment of anorectal function.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To evaluate anal pressure profiles during rest and squeeze pull\u2010through maneuvers in FI patients and normal subjects (NS) using Fecobionics and to compare with current technology.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with FI (Rome IV criteria) and healthy controls were recruited. FI severity was assessed with FISI questionnaire. Anal pull\u2010through maneuvers were performed using Fecobionics and anorectal manometry (ARM) during rest and maximum anal squeeze, and the pull\u2010through pressures were measured and compared. Data were expressed as median and quartiles. Non\u2010parametric statistical testing was done.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010four FI patients and 20 NS participated. The FISI score was 0 (0\u20130) in the NS group and 28 (22\u201335) in the FI group. Resting pull\u2010through pressure did not differ between FI patients (82.0 (56.0\u2013145.5 cmH\n 2<\/jats:sub>\n O)) and NS (99.5 (64.8\u2013138.5 cmH\n 2<\/jats:sub>\n O)), whereas the maximum squeeze pressure was lower in FI (124.5 (85.5\u2013208.8 cmH\n 2<\/jats:sub>\n O)) than NS (169.5 (122.3\u2013262.0 cmH\n 2<\/jats:sub>\n O)) (\n p<\/jats:italic>\n \u2009<\u20090.02). Furthermore, the difference between maximum squeeze and resting pressure differed between groups (\n p<\/jats:italic>\n \u2009<\u20090.01). ARM did not show differences between the groups at rest or maximum squeeze (\n p<\/jats:italic>\n \u2009>>0.2). Strong association was found between the resting and contracted pull\u2010through pressures (\n r<\/jats:italic>\n \u2009=\u20090.74,\n p<\/jats:italic>\n \u2009<\u20090.001). Similar strong association was found in traumatic, atraumatic, passive, and urge FI subgroups. Data were not influenced by the magnitude of internal or external anal sphincter defects. Bland Altman plots showed agreement between Fecobionics pull\u2010throughs and ARM.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Fecobionics device showed lower squeeze pressures in FI patients compared to NS during anal pull\u2010through procedure and strong associations between these pressures and FI subgroups.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.70318","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T03:59:32Z","timestamp":1775879972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resting and Squeeze Anal Pull\u2010Through Assessments by Fecobionics Demonstrate Weak Anal Sphincters in Patients With Fecal Incontinence"],"prefix":"10.1111","volume":"38","author":[{"given":"Giuliana Barron","family":"Del Solar","sequence":"first","affiliation":[{"name":"California Medical Innovations Institute San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Guo","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Long","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yan","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Aziz","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaram","family":"Asadi","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-0107","authenticated-orcid":false,"given":"Karlo","family":"Fidel","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish S. C.","family":"Rao","sequence":"additional","affiliation":[{"name":"J. WellStar MCG Health Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-2845","authenticated-orcid":false,"given":"Hans","family":"Gregersen","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(88)90223-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000196190.42296.a9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.08.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00827.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.054"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002670"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12859"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.043"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00242.2020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000342"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000354"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14208"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-018-02149-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-021-02439-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000491"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003532"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.057"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236199"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237236"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15338"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soda.2023.100117"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151\u2010025\u201003125\u20103"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.818"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.057"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4044134"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18013"},{"key":"e_1_2_10_30_1","first-page":"1","article-title":"Anorectal Friction Force Is Reduced in Fecal Incontinence","volume":"4","author":"Gregersen H.","year":"2025","journal-title":"Gastroenterology. 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