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The term \u201claryngopharyngeal reflux\u201d has variable definitions in the literature and has been used to describe symptomatic patients with or without objective reflux, often leading to prolonged\/unnecessary treatment trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The San Diego consensus introduced the term laryngopharyngeal symptoms (LPS) to describe upper aerodigestive symptoms with potential relationship to reflux physiology, including cough, regurgitation, throat pain, throat clearing, excess phlegm, and hoarseness\/voice change. This review describes presentation, health care burden and risk stratification of throat and airway symptoms in light of the San Diego consensus definitions and clinical approach. Laryngopharyngeal reflux disease (LPRD) requires objective evidence of pathologic reflux in addition to LPS. Importantly, LPS alone do not predict LPRD. While various validated patient\u2010reported outcome instruments are available, only some are LPS\/LPRD\u2010specific, and all lack specificity for making a diagnosis of LPRD. These instruments may have value in tracking symptoms over time and post\u2010treatment. Concurrent typical reflux symptoms may prompt empiric anti\u2010reflux medication trials as initial therapy. Risk stratification scores have been developed for the purpose of directing upfront therapy for high\u2010risk patients and investigation for intermediate\/low\u2010risk patients, but their clinical use needs further validation. Objective diagnosis of LPRD provides confidence in escalation of reflux interventions. Life\u2010threatening long\u2010term sequelae are infrequent in LPS\/LPRD, although impact on quality of life and healthcare burden can be profound.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70339","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:01:37Z","timestamp":1778479297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Presentation, Health Care Burden, and Risk Stratification"],"prefix":"10.1111","volume":"38","author":[{"given":"Walter W.","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Myers","sequence":"additional","affiliation":[{"name":"Oesophageal Function, the Queen Elizabeth Hospital &amp; Discipline of Surgery Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Harvard Medical School, Boston, MA and Division of Otolaryngology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Misono","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-8210","authenticated-orcid":false,"given":"Chien\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-2792","authenticated-orcid":false,"given":"Enrique","family":"Coss\u2010Adame","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, GI Motility Lab Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-6925","authenticated-orcid":false,"given":"Philip","family":"Weissbrod","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Yadlapati","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. 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