{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:46:01Z","timestamp":1785833161429,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Proton pump inhibitors (PPIs) are widely used for upper gastrointestinal symptoms but are frequently prescribed inappropriately and often continued without clear indications. Deprescribing PPIs can be challenging due to symptom recurrence or rebound acid hypersecretion. The mucosal protective agent Poliprotect, a natural formulation with barrier, antioxidant, and anti\u2010inflammatory properties, has shown non\u2010inferiority to omeprazole in non\u2010erosive heartburn and epigastric pain syndrome (EPS) without affecting intestinal microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the role of Poliprotect formulation (neoBianacid) in maintaining symptom control after PPI withdrawal in patients with endoscopy\u2010negative heartburn (HRTB) and EPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc analysis used data from a multicenter, double\u2010blind RCT including 125 endoscopy\u2010negative patients (80 with HRTB, 45 with EPS) treated with omeprazole 20\u2009mg\/day for 4\u2009weeks, followed by 4\u2009weeks of on\u2010demand Poliprotect after PPI discontinuation. Outcomes included symptom severity (VAS), responder rate (\u2265\u200950% VAS reduction), use of rescue medication, quality of life (GIQLI), gastrointestinal symptoms (GSRS), treatment satisfaction, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of deprescription, mean VAS scores remained stable, and 69.5% of PPI responders (65.8%, HRTB, and 76.2%, EPS) maintained symptom control. Additionally, 31% of PPI non\u2010responders (33.3%, HRTB, and 27.3%, EPS) became responders with Poliprotect. Rescue antacid use and quality of life scores were not significantly changed. No adverse events were reported during the deprescribing phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>On\u2010demand Poliprotect was associated with maintenance of symptom control after PPI withdrawal and outcome improvement in approximately one\u2010third of PPI non\u2010responders. Poliprotect appears to be a safe, well\u2010tolerated, and promising strategy to support PPI discontinuation in endoscopy\u2010negative heartburn and EPS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/Clinicaltrial.gov\">Clinicaltrial.gov<\/jats:ext-link>\n                      (NCT03238534) and EudraCT Database (2015\u2013005216\u201015)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70370","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:45:18Z","timestamp":1780379118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poliprotect in the PPI Deprescription Phase of Endoscopy\u2010Negative Heartburn and Epigastric Pain Syndrome Patients: An RCT Post Hoc Analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-1328","authenticated-orcid":false,"given":"Enrico Stefano","family":"Corazziari","sequence":"first","affiliation":[{"name":"Centro di Eccellenza in Malattie Gastroenterologiche, Ospedale Isola Tiberina  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Medicina Interna e Gastroenterologia, CEMAD Centro Malattie Dell'apparato Digerente, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"D'Alba","sequence":"additional","affiliation":[{"name":"Azienda Opedaliera S.Camillo\u2010Forlanini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-4463","authenticated-orcid":false,"given":"Valeria","family":"D'Ovidio","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology and Digestive Endoscopy S.Eugenio Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero","family":"Riggio","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Translazionale e di Precisione Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Passaretti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Gastrointestinal Endoscopy Unit Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Medico\u2010Chirurgiche e Medicina Translazionale Universit\u00e0 Sapienza Roma, Ospedale Universitario Sant'Andrea  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cicala","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Campus Bio Medico University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Repici","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrio","family":"Bassotti","sequence":"additional","affiliation":[{"name":"Gastroenterology &amp; Hepatology Section, Department of Medicine &amp; Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-1145","authenticated-orcid":false,"given":"Carolina","family":"Ciacci","sequence":"additional","affiliation":[{"name":"PO di Malattie Dell'apparato Digerente, Universit\u00e0 di Salerno, AOU San Giovanni di Dio e Ruggi D'aragona  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Sabatino","sequence":"additional","affiliation":[{"name":"First Department of Medicine University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences and Center for Advanced Studies and Technology (CAST) \u2018G. 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