{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:42:35Z","timestamp":1787506955482,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Magnesium\u2010rich mineral water influences stool consistency and bowel habits. However, randomized controlled trials directly comparing magnesium\u2010rich mineral water with soft water using standardized bowel outcomes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, randomized, parallel\u2010group trial enrolled 40 healthy subjects who did not meet Rome IV criteria for chronic constipation or irritable bowel syndrome. After a 7\u2010day observation period, participants consumed either soft water or magnesium\u2010rich mineral water (1\u2009L\/day) for 14\u2009days. The primary endpoint was change in weekly mean Bristol Stool Form Scale (BSFS) score from baseline to intervention week 2, analyzed using analysis of covariance. Secondary endpoints included spontaneous bowel movements (SBM; bowel movements without rescue medication), complete spontaneous bowel movements (CSBM; SBM with a sensation of complete evacuation), subjective global improvement, time to first SBM, and daily total fluid intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      All participants completed the trial. Compared with soft water, magnesium\u2010rich mineral water significantly increased BSFS score at week 1 and week 2 (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Weekly frequencies of SBM and CSBM were higher in the magnesium\u2010rich mineral water group. Subjective improvement at week 2 was more frequent with magnesium\u2010rich mineral water. Compared with the observation period, no difference in water intake was observed between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>In healthy subjects, magnesium\u2010rich mineral water was associated with stool softening and increased bowel movement frequency. No safety concerns were observed during the study period. These findings support further investigation of magnesium\u2010rich mineral water as a strategy for modulating bowel habits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70378","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:40:53Z","timestamp":1781329253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Magnesium\u2010Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1785-8433","authenticated-orcid":false,"given":"Hideki","family":"Yoneda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hyogo Medical University School of Medicine  Nishinomiya Hyogo 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