{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:22:58Z","timestamp":1786461778705,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is the most frequent abdominal\u2010pain\u2013predominant disorder of gut\u2013brain interaction (DGBI). Because the pediatric Rome IV criteria require abdominal pain and stool changes for at least 4\u2009days per month over 2\u2009months, adolescents whose pain coincides with menstruation may be misclassified as IBS. We aimed to determine whether menstrual\u2010associated gastrointestinal symptoms contribute to the reported IBS prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional study of 3521 school\u2010aged females (10\u201316\u2009years) from public and private schools in Colombia. Participants completed the validated Spanish Rome IV Pediatric Questionnaire for Gastrointestinal Symptoms, which included questions on temporal relation between pain, bowel habits, and menstruation. These symptoms were defined as occurring during days of active bleeding, without inclusion of a pre\u2010 or postmenstrual window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 3336 analyzable surveys (mean age 13.3\u2009\u00b1\u20091.8\u2009years), 2926 (87.7%) were postmenarcheal. Overall, 609\/2926 (20.8%) met criteria for \u2265\u20091 DGBI, including 45 participants (1.5%) who met criteria for IBS. Among postmenarcheal participants with IBS, 62.2% reported abdominal pain and bowel\u2010habit changes exclusively during menstruation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A substantial proportion of adolescents meeting pediatric Rome IV criteria for IBS reported symptoms confined to menstruation, demonstrating a clinically relevant diagnostic overlap between dysmenorrhea and IBS. Because the Rome IV pediatric algorithm does not distinguish menstrual\u2010only pain from chronic abdominal pain, menstrual\u2010associated gastrointestinal symptoms may resemble those of IBS and complicate diagnostic decision\u2010making. Further studies are needed to clarify whether these presentations reflect menstrual\u2010related gastrointestinal symptoms alone or a distinct subset of DGBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70382","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:35:46Z","timestamp":1782192946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Menstrual\u2010Associated Gastrointestinal Symptoms and Their Impact on\n                    <scp>IBS<\/scp>\n                    Diagnosis in Adolescents"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9448-8148","authenticated-orcid":false,"given":"Samantha","family":"Arrizabalo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisia","family":"Banegas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4062-5326","authenticated-orcid":false,"given":"Carlos Alberto","family":"Velasco\u2010Benitez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Alejandra","family":"Velasco\u2010Suarez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0615-2691","authenticated-orcid":false,"given":"Manuel","family":"Linares","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Saps","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.04.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024\u2010067677"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703\u2010200612000\u201000001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2012.07257.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.74"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.131"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13509"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12826"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(96)70246\u20109"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004\u20102764"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6725"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001391"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04409.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106874\u201014\u201014"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/534204"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533264"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14992"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14950"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001610\u2010200601000\u201000002"},{"issue":"11","key":"e_1_2_11_25_1","first-page":"1973","article-title":"Functional Bowel Disorders in Women With Dysmenorrhea","volume":"89","author":"Crowell M. 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