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LPS manifest as persistent or disproportionate symptoms despite minimal or inconsistent evidence of reflux exposure. Emerging evidence suggests that hyperresponsiveness, hypervigilance, and symptom\u2010specific anxiety are more strongly associated with LPS than objective reflux metrics and may contribute to symptom persistence through heightened attention to perceived irritation and protective behavioral responses. Repeated peripheral sensory input may further contribute to central sensitization and lower perceptive thresholds. While these behavioral and neurophysiological processes may be partially improved by reducing reflux exposure, behavioral therapies that address the multidimensional nature of LPS may provide additional benefit. Laryngeal Recalibration Therapy addresses LPS by retraining maladaptive laryngeal behaviors, enhancing vagal tone via heart rate variability biofeedback, and cognitive reframing to reduce symptom amplification. Meta\u2010therapy, a clinical dialogue approach used in speech\u2010language pathology to facilitate behavioral change, alongside psychological interventions such as mindfulness meditation, cognitive\u2010behavioral therapy, and gut\u2010directed hypnotherapy, may further target cognitive\u2013affective processes that shape perception. Behavioral interventions can be combined with neuromodulators, particularly delta ligands such as gabapentin in patients with chronic cough, and tricyclic antidepressants or selective serotonin reuptake inhibitors in select cases. Effective management relies on multidisciplinary collaboration, integration of reflux\u2010directed and behavioral therapies, and patient\u2010centered education that supports adaptive symptom interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70383","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:43:48Z","timestamp":1782193428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Interdisciplinary Considerations and Management"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9765-1752","authenticated-orcid":false,"given":"Erin","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of California San Diego Health  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-3955","authenticated-orcid":false,"given":"Livia","family":"Guadagnoli","sequence":"additional","affiliation":[{"name":"Kenneth C. Griffin Esophageal Center Northwestern Medicine, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Barkmeier\u2010Kraemer","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences &amp; Disorders, Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Dion","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gartner\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology Carlow University  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Physiology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Mons  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Kenneth C. 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