{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:09Z","timestamp":1791919689407,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence suggests psychological factors including personality traits can have impact on the development and course of irritable bowel syndrome (IBS) and associated health\u2010related quality of life (HrQoL), with large individual heterogeneity. Main aim of this study was to examine between\u2010persons associations and within\u2010sample concurrent associations of the personality traits neuroticism, extraversion, conscientiousness, openness and agreeableness with gastrointestinal (GI) symptoms, psychological factors and HrQoL in IBS\u2010patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectional data from an observational IBS\u2010study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194, mean age 51.36\u2009years, 74.4% female) was used. Patients completed the Big Five Inventory (BFI)\u201044 questionnaire regarding personality traits, and questionnaires on symptom severity (GSRS\u2010IBS), general anxiety (HADS\u2010A, GAD\u20107), GI\u2010specific anxiety (VSI), and HrQoL (36\u2010SF). A multivariable regression model and a network correlation analysis were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Neuroticism showed the most relevant between\u2010persons associations, confirmed by within\u2010sample concurrent associations: associated with\n                      <jats:italic>increased<\/jats:italic>\n                      GI\u2010specific anxiety (\n                      <jats:italic>B<\/jats:italic>\n                      7.234,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), general anxiety (\n                      <jats:italic>B<\/jats:italic>\n                      0.954,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), and\n                      <jats:italic>decreased<\/jats:italic>\n                      mental HrQoL (\n                      <jats:italic>B<\/jats:italic>\n                      \u20143.576,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Extraversion showed an opposing pattern including\n                      <jats:italic>increased<\/jats:italic>\n                      mental HrQoL (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20094.266,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with strong association to neuroticism. While no significant between\u2010person associations emerged between abdominal pain and personality traits, significantly associated to higher general anxiety (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20096.304,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and GI\u2010specific anxiety (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20090.034,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were shown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reinforces the association between personality traits and IBS, highlighting the integral connection to not only other psychological factors but also GI\u2010symptoms. These findings support a multifactorial, personalized approach to IBS, advocating for the integration of personality assessment\u2014particularly neuroticism and extraversion\u2014into the biopsychosocial model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70384","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:21:22Z","timestamp":1782105682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Personality Traits and Irritable Bowel Syndrome\u2014Insights From an Exploratory Cohort Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-8014","authenticated-orcid":false,"given":"Sylvester R.","family":"Groen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsa Zsa R. M.","family":"Weerts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-3191","authenticated-orcid":false,"given":"Lisa","family":"Vork","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatan","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Leue","sequence":"additional","affiliation":[{"name":"MHeNS, School for Mental Health and Neuroscience Maastricht University  Maastricht the Netherlands"},{"name":"Department of Psychiatry and Medical Psychology Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-1628","authenticated-orcid":false,"given":"Sandra","family":"Mulkens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Medical Psychology Maastricht University Medical Center+  Maastricht the Netherlands"},{"name":"Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna W.","family":"Kruimel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad A. 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