{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:38:18Z","timestamp":1790969898792,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Meal\u2010related symptoms are commonly identified in disorders of gut\u2013brain interaction (DGBIs). Gastroduodenal low\u2010grade inflammation involving mucosal eosinophils and\/or mast cells has been previously described in patients with DGBIs. In children with DGBIs, we sought to determine potential relationships between gastric and duodenal mucosal eosinophils and mast cells with specific meal\u2010related and non\u2010GI somatic symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred eight youth with AP\u2010DGBI were evaluated. All patients underwent esophagogastroduodenoscopy (EGD) with biopsies taken from the gastric antrum and duodenum. Patients completed symptom and BASC\u20103 questionnaires to evaluate somatization and the presence of specific meal\u2010related and non\u2010GI somatic symptoms. A single observer blinded to clinical data reported maximum density of eosinophils and mast cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Mucosal eosinophil and mast cell counts did not differ between FD and IBS nor between FD subtypes. After correction for multiple comparisons, there were no associations between eosinophil or mast cell counts with meal\u2010related symptoms. In contrast, duodenal mast cells were positively associated with headaches, dizziness, fatigue, and rhinitis, with predominantly medium effect sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Meal\u2010related symptoms are common in youth with DGBIs, but do not appear to be associated with mucosal eosinophils and mast cell counts. The positive associations of duodenal mast cells with non\u2010GI somatic complaints suggest future studies should determine whether treatments targeting mast cells are beneficial for ameliorating these symptoms in youth with DGBIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70406","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:22:33Z","timestamp":1785471753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Meal\u2010Related and Somatic Symptoms With Mucosal Eosinophil and Mast Cell Counts in Youth With Disorders of Gut\u2013Brain Interaction"],"prefix":"10.1111","volume":"38","author":[{"given":"Jennifer V.","family":"Schurman","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; Nutrition Children's Mercy Kansas City  Kansas City Missouri USA"},{"name":"Department of Pediatrics University of Missouri\u2010Kansas City School of Medicine  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-0967","authenticated-orcid":false,"given":"Craig A.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; Nutrition Children's Mercy Kansas City  Kansas City Missouri USA"},{"name":"Department of Pediatrics University of Missouri\u2010Kansas City School of Medicine  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-0758","authenticated-orcid":false,"given":"Kara G.","family":"Margolis","sequence":"additional","affiliation":[{"name":"New York University  New York New York USA"},{"name":"Department of Molecular Pathobiology New York University College of Dentistry  New York New York USA"},{"name":"Department of Pediatrics New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda A. L.","family":"van Tilburg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina  Chapel Hill North Carolina USA"},{"name":"School of Social Work University of Washington  Seattle Washington USA"},{"name":"Department of Graduate Medical Education Cape Fear Valley Health  Fayetteville North Carolina USA"},{"name":"Department of Health System Sciences Methodist University Cape Fear Valley Health School of Medicine  Fayetteville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6898-7231","authenticated-orcid":false,"given":"Corey","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Connecticut Children's Medical Center  Hartford Connecticut USA"},{"name":"University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenal","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; Nutrition Children's Mercy Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-0991","authenticated-orcid":false,"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Nutrition Research Center Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-0036","authenticated-orcid":false,"given":"Bruno P.","family":"Chumpitazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12185"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2016.04.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12894"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00222-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13304"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.01.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-229"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0377-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13718"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13192"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12250"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12419"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001812"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1363c"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12477"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.047"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.69.1.85"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001373"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412472070"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01291-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord1010013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0495-3"},{"key":"e_1_2_10_26_1","volume-title":"Behavior Assessment for Children: Third Edition. 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