{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:20:48Z","timestamp":1787980848039,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Magnetic resonance imaging (MRI) enables non\u2010invasive, radiation\u2010free assessment of gastric emptying, intragastric liquid distribution, and motility. However, characterization of the stomach function in patients with functional dyspepsia (FD) remains limited. We aimed to apply the Virtual Gaster (VIGA) MRI platform to characterize gastric geometry, emptying dynamics, and motility patterns in patients with FD compared with healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six adults with Rome IV\u2013defined FD and twenty HCs underwent static and dynamic gastric MRI during fasting, gastric filling with a liquid meal, and emptying. VIGA was used to quantify compartmental gastric volumes (fundus, corpus, antrum), estimate gastric half\u2010emptying time (T50), and assess motility parameters. Symptoms were evaluated using PAGI\u2010SYM and postprandial visual analog scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gastric half\u2010emptying time was shorter in FD than in HCs (47.7\u2009\u00b1\u200927.8 vs. 68.0\u2009\u00b1\u200915.7\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). FD patients showed reduced fundic content volumes with a relative shift of content toward the corpus and antrum (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Gastric dysrhythmias were more frequent in FD (50% vs. 10%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and distal contraction propagation with rhythmic activity was slower during both accommodation (3.19\u2009\u00b1\u20090.83 vs. 4.10\u2009\u00b1\u20091.21\u2009mm\/s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and emptying (3.31\u2009\u00b1\u20090.61 vs. 3.93\u2009\u00b1\u20091.02\u2009mm\/s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Exploratory analyses showed moderate inverse correlations between symptom severity, particularly bloating and heartburn, and antral volume or contraction velocity during accommodation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VIGA\u2010enabled gastric MRI identified differences in intragastric liquid distribution, gastric liquid emptying, and distal motility between FD patients and healthy controls. The moderate correlation with symptoms supports its value for characterizing regional gastric physiology in health and disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70410","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:40:57Z","timestamp":1787085657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MRI<\/scp>\n                    \u2010Based Gastric Function Assessment in Patients With Functional Dyspepsia"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5830-0918","authenticated-orcid":false,"given":"Vadim","family":"Rosca","sequence":"first","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology Iasi \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-6537","authenticated-orcid":false,"given":"Donghua","family":"Liao","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-7430","authenticated-orcid":false,"given":"Esben Bolvig","family":"Mark","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Rusu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi  Iasi Romania"},{"name":"Department of Radiology \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-2584","authenticated-orcid":false,"given":"Maria Bitsch","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-9340","authenticated-orcid":false,"given":"Liliana","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi  Iasi Romania"},{"name":"Department of Radiology \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-2656","authenticated-orcid":false,"given":"Vasile","family":"Drug","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology Iasi \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-1884","authenticated-orcid":false,"given":"Christina","family":"Brock","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-0070","authenticated-orcid":false,"given":"Jens Br\u00f8ndum","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Radiology Research Center, Department of Radiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-964X","authenticated-orcid":false,"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.22551\/2025.46.1201.10310"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201054716\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30469\u20104"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330733"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343935"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.499"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445226"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358111"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000393"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.039"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14371"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14239"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/OJEMB.2023.3261224"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000900"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14396"},{"key":"e_1_2_11_18_1","volume-title":"Neurogastro Meeting, September 4\u20136, 2025 Queen Mary University, London, UK","author":"Liao D.","year":"2025"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.70470"},{"key":"e_1_2_11_20_1","volume-title":"Neurogastro Meeting, September 4\u20136, 2025 Queen Mary University, London, UK","author":"Mark E. 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