{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:45:26Z","timestamp":1789497926187,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric emptying scintigraphy (GES) is considered the standard for differentiating gastroparesis from functional dyspepsia and other foregut disorders characterized by nausea and vomiting but provides only a brief physiologic snapshot that may not accurately reflect daily function. We utilized a non\u2010invasive wireless patch system (WPS) to characterize multiday gastric myoelectrical activity, evaluate its relationship with GES, and assess changes following a therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults referred for GES for symptoms thought to represent gastroparesis were enrolled in a prospective study. Patients wore a WPS for up to 6\u2009days, starting on the day of scintigraphy. Gastric myoelectrical activity was analyzed and categorized into relatively weak, relatively moderate, and relatively strong activity phenotypes. A subset of patients underwent repeat monitoring following individualized therapeutic interventions (e.g., anti\u2010emetics, proton pump inhibitors, lifestyle changes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight patients (mean age 44; 79% female) completed the study. GES identified delayed gastric emptying in 18%, rapid in 22%, and normal in 60% of subjects. During the 4\u2010h concurrent GES window, gastric activity in patients with delayed emptying was lower, but this difference did not reach statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). When compared to the full multiday recording period, GES results showed no correlation with the myoelectric readings. Significant day\u2010to\u2010day variability was observed, both random and systemic. In the latter category, a \u201cTest\u2010Day\u201d dip was observed with gastric activity lowest on Day 1 (GES test day) and increasing significantly on subsequent days, stabilizing by Day 4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Healthy control subjects recorded during normal daily routines showed no such day\u2010to\u2010day variation. In the retesting cohort, anti\u2010emetics produced robust increases in gastric amplitude, whereas PPIs showed minimal impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The WPS effectively captures distinct gastric phenotypes and quantifies physiologic responses to therapy in both gastric and intestinal regions, demonstrating its clinical utility as a robust tool for evaluating and managing foregut symptoms in real\u2010world settings. Importantly, the multiday WPS highlights significant day\u2010to\u2010day physiologic variability in gastric activity that extends beyond the single\u2010day GES \u2018snapshot\u2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70413","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:37:47Z","timestamp":1785814667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond the Snapshot: Overcoming\n                    <scp>GES<\/scp>\n                    Limitations to Characterize Gastric Phenotypes and Therapeutic Responses Using a 6\u2010Day Ambulatory Wearable Monitor"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-7970","authenticated-orcid":false,"given":"Brian E.","family":"Lacy","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic in Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-7012","authenticated-orcid":false,"given":"David J.","family":"Cangemi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic in Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-8937","authenticated-orcid":false,"given":"Lindsay","family":"Axelrod","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc., Fogarty Innovation  Mountain View California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-8887","authenticated-orcid":false,"given":"Steve","family":"Axelrod","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc., Fogarty Innovation  Mountain View California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-6064","authenticated-orcid":false,"given":"Anand","family":"Navalgund","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc., Fogarty Innovation  Mountain View California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2008.01097.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.12.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000728"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.085365"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2008.01081.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000677"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001562"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.08.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13365"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.01.230"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14862"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.107.048116"},{"key":"e_1_2_8_15_1","first-page":"S9","article-title":"Monitoring Gastric Myoelectric Activity After Pancreaticoduodenectomy for Diet Readiness","volume":"20","author":"Dua M. 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