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Quantitative sensory testing (QST) is a psychophysical method that has the potential to provide a measure of pain processing, as well as insight into pain pathophysiology and the prediction of response to specific therapies. We aimed to characterize somatic QST in a well\u2010characterized cohort of patients with gastroparesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with scintigraphically defined gastroparesis underwent abdominal QST with assessment of mechanical pain: pain sensitivity (thresholds and tolerance) and pain facilitation (temporal summation). The Patient Assessment of Upper GI Symptoms (PAGI\u2010SYM) upper and lower abdominal pain scales were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QST was performed on 264 participants (87% female; age\u2009=\u200918\u201378\u2009years). In both the upper and lower abdomen, smaller pain thresholds and lower pain tolerance were significantly associated with greater PAGI\u2010SYM upper abdominal pain severity (\n                      <jats:italic>b<\/jats:italic>\n                      's\u2009=\u20090.07\u20130.15;\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009=\u20090.007\u20130.02), but not lower abdominal pain severity. Scores on the PAGI\u2010SYM upper and lower abdominal pain scales were moderately correlated (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No significant associations were found for temporal summation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings suggest self\u2010reported\n                      <jats:italic>upper<\/jats:italic>\n                      abdominal pain severity correlated with both lower and upper abdominal mechanical pain sensitivity\u2014possibly reflecting secondary sensitization of the abdominal wall, due to viscerosomatic convergence in upper abdominal somatic segments. Lower abdominal pain severity association with only upper (but not lower) abdominal QST may be due to cross\u2010organ sensitization. Further investigations are needed to test the clinical utility of abdominal QST in gastric sensorimotor disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT01696747\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70443","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:31:59Z","timestamp":1790231519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abdominal Pain Sensitization Connected With Upper but Not Lower Abdominal Pain in Adults With Gastroparesis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-3256","authenticated-orcid":false,"given":"Helen","family":"Burton\u2010Murray","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily P.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-765X","authenticated-orcid":false,"given":"Laura A.","family":"Miriel","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-7269","authenticated-orcid":false,"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Science Center  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha","family":"Moshiree","sequence":"additional","affiliation":[{"name":"Wake Forest University  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-0831","authenticated-orcid":false,"given":"Madhusudan","family":"Grover","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-5235","authenticated-orcid":false,"given":"Gianrico","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-0036","authenticated-orcid":false,"given":"Bruno P.","family":"Chumpitazi","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-0991","authenticated-orcid":false,"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Baylor University  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-6452","authenticated-orcid":false,"given":"Geoffrey A.","family":"Preidis","sequence":"additional","affiliation":[{"name":"Baylor University  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-5161","authenticated-orcid":false,"given":"Thomas L.","family":"Abell","sequence":"additional","affiliation":[{"name":"University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-2871","authenticated-orcid":false,"given":"William L.","family":"Hasler","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Brigham &amp; 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