{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:53:40Z","timestamp":1790931220908,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic nausea is commonly associated with disorders of gut\u2010brain interaction (DGBI). Pediatric functional nausea (FN) is defined as predominant nausea generally unrelated to meals. It is unclear if FN is a distinct entity or clustered with pain\u2010associated DGBI. This multi\u2010center study aimed to investigate the burden and comorbidities of FN and compare it to other DGBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients ages 8\u201321\u2009years with DGBI were enrolled in a cross\u2010sectional, multi\u2010center observational registry across seven outpatient gastroenterology clinics and classified by Rome IV criteria. FN was compared to non\u2010FN DGBI using validated symptom surveys: (1) Nausea Severity Scale (NSS), (2) Abdominal Pain Index (API), (3) PROMIS Global Health Scale (GHS), (4) PROMIS Pediatric Anxiety, (5) PROMIS Pediatric Depression, (6) Children's Somatization Inventory (CSI), and (7) Functional Disability Inventory (FDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      292 subjects were analyzed. Fifty (17%) met FN criteria, of which 72% were female. Eighty\u2010four and 32% of FN patients also met criteria for functional dyspepsia (FD) post\u2010prandial distress subtype and irritable bowel syndrome (IBS), respectively. FN versus non\u2010FN reported greater abdominal pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). FN versus IBS more commonly had long\u2010term nausea and abdominal pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), postural dizziness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), migraines (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lower global health (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), along with greater anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Children who meet formal FN criteria do not have isolated nausea. FN overlaps highly with pain\u2010associated DGBI, and nearly all FN patients report abdominal pain. FN is coupled with extra\u2010intestinal symptoms, mental health comorbidities, and poor global health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70447","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:10:41Z","timestamp":1790928641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Nausea Is Not Just Nausea: A Multi\u2010Center, Cross\u2010Sectional Study of Children and Young Adults"],"prefix":"10.1111","volume":"38","author":[{"given":"Khalil","family":"El\u2010Chammas","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hagenstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-0584","authenticated-orcid":false,"given":"Ashish","family":"Chogle","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Rady Children's Health of Orange County  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-079X","authenticated-orcid":false,"given":"Neha","family":"Santucci","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio 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Nutrition Atrium Health Levine Children's Hospital  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-8492","authenticated-orcid":false,"given":"Jason E.","family":"Dranove","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition Atrium Health Levine Children's Hospital  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-3060","authenticated-orcid":false,"given":"Rachel","family":"Rosen","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology Children's Hospital Boston  Boston Massachusetts 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