{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:27:11Z","timestamp":1793766431787,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) shows substantial geographic variability in symptom presentation, but regional differences in the clinical relevance of bloating remain poorly understood. We aimed to characterize regional differences in IBS phenotype, symptom burden, psychological and quality\u2010of\u2010life measures, and meal\u2010related symptoms between Asian\/Australian and European populations, with particular emphasis on the contribution of bloating to disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross\u2010sectional analysis of the multinational AEGIS survey including adults fulfilling Rome IV criteria for IBS from 11 centers across Asia\/Australia and Europe. Participants completed validated assessments of IBS subtype, symptom severity, quality of life, psychological burden, and dietary triggers. Regional comparisons used nonparametric and chi\u2010square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1074 participants, 339 met Rome IV criteria for IBS. The proportion of IBS patients was lower in Asia\/Australia than in Europe (20.9% vs. 40.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). IBS\u2010D (57.1% vs. 35.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) predominated in Asia\/Australia, whereas IBS\u2010M (31.6% vs. 20.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028) was more common in Europe. European patients demonstrated higher psychological burden and greater overall symptom severity despite comparable abdominal pain intensity. Bloating severity was significantly higher in European participants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and showed a substantially stronger association with impaired quality of life than pain (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.552,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 vs.\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.260,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Postprandial symptoms were more common in Europe, whereas in Asia\/Australia, they were associated with greater consumption of dairy products, gluten\u2010containing foods, coffee, and carbonated beverages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IBS phenotype and symptom burden differ across regions. Bloating, rather than abdominal pain, was more strongly associated with impaired quality of life, supporting symptom\u2010centered and culturally tailored IBS management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70453","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:56:42Z","timestamp":1791791802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global IBS, Local Patterns: Regional Variability in Pain, Bloating, and Impact on Daily Life Among Asian\/Australian and European Patients From the Aegis Epidemiology Survey"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-1147","authenticated-orcid":false,"given":"Christian","family":"von Muhlenbrock","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"},{"name":"Department of Internal Medicine, Center of Digestive Diseases Universidad de los Andes  Santiago Chile"},{"name":"Gastroenterology Section Hospital Clinico Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-7904","authenticated-orcid":false,"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7823-016X","authenticated-orcid":false,"given":"Cedric","family":"Van de Bruaene","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-8500","authenticated-orcid":false,"given":"Lukas Michaja","family":"Balsiger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-1539","authenticated-orcid":false,"given":"Luis G.","family":"Alcala\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, Department of Digestive Diseases Vall d'Hebron University Hospital  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd)  Barcelona Spain"},{"name":"Department of Medicine Universitat Autonoma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-5266","authenticated-orcid":false,"given":"Karin","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center of Digestive Diseases Universidad de los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Colomier","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AEGIS working group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-0903","authenticated-orcid":false,"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism (Chrometa), Translational Research Center for Gastrointestinal Disorders (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618821804"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14567"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.07.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-016-0070-8"},{"issue":"11","key":"e_1_2_11_6_1","first-page":"729","article-title":"Pathophysiology, Evaluation, and Treatment of Bloating: Hope, Hype, or Hot Air","volume":"7","author":"Lacy B. 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