{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:56:59Z","timestamp":1789639019631,"version":"4.0.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":551,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Manganese (Mn) is an essential nutrient required for plant growth, in particular in the process of photosynthesis. Plant performance is influenced by various environmental stresses including contrasting temperatures, light or nutrient deficiencies. The molecular responses of plants exposed to such stress factors in combination are largely unknown.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Screening of 108 <jats:italic>Arabidopsis thaliana<\/jats:italic> (Arabidopsis) accessions for reduced photosynthetic performance at chilling temperatures was performed and one accession (Hog) was isolated. Using genetic and molecular approaches, the molecular basis of this particular response to temperature (G\u00a0\u00d7\u00a0E interaction) was identified.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Hog showed an induction of a severe leaf chlorosis and impaired growth after transfer to lower temperatures. We demonstrated that this response was dependent on the nutrient content of the soil. Genetic mapping and complementation identified <jats:italic><jats:styled-content style=\"fixed-case\">NRAMP<\/jats:styled-content>1<\/jats:italic> as the causal gene. Chlorotic phenotype was associated with a histidine to tyrosine (H239Y) substitution in the allele of Hog <jats:styled-content style=\"fixed-case\">NRAMP<\/jats:styled-content>1. This led to lethality when Hog seedlings were directly grown at 4\u00b0C.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Chemical complementation and hydroponic culture experiments showed that Mn deficiency was the major cause of this G\u00a0\u00d7\u00a0E interaction. For the first time, the <jats:styled-content style=\"fixed-case\">NRAMP<\/jats:styled-content>\u2010specific highly conserved histidine was shown to be crucial for plant performance.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.12737","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T09:02:43Z","timestamp":1393491763000},"page":"1173-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Conserved histidine of metal transporter At<scp>NRAMP<\/scp>1 is crucial for optimal plant growth under manganese deficiency at chilling temperatures"],"prefix":"10.1111","volume":"202","author":[{"given":"Anna","family":"Ihnatowicz","sequence":"first","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk ul. 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