{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:55Z","timestamp":1787015755941,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":431,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Iron (Fe) and copper (Cu) homeostasis are tightly linked across biology. In previous work, Fe deficiency interacted with Cu\u2010regulated genes and stimulated Cu accumulation.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          The C940\u2010fe (\n                          <jats:italic>fefe<\/jats:italic>\n                          ) Fe\u2010uptake mutant of melon (\n                          <jats:italic>Cucumis melo<\/jats:italic>\n                          ) was characterized, and the\n                          <jats:italic>fefe<\/jats:italic>\n                          mutant was used to test whether Cu deficiency could stimulate Fe uptake. Wild\u2010type and\n                          <jats:italic>fefe<\/jats:italic>\n                          mutant transcriptomes were determined by\n                          <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                          \u2010seq under Fe and Cu deficiency.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>FeFe<\/jats:italic>\n                          \u2010regulated genes included core Fe uptake, metal homeostasis, and transcription factor genes. Numerous genes were regulated by both Fe and Cu. The\n                          <jats:italic>fefe<\/jats:italic>\n                          mutant was rescued by high Fe or by Cu deficiency, which stimulated ferric\u2010chelate reductase activity,\n                          <jats:italic>\n                            <jats:styled-content style=\"fixed-case\">FRO<\/jats:styled-content>\n                            2\n                          <\/jats:italic>\n                          expression, and Fe accumulation. Accumulation of Fe in Cu\u2010deficient plants was independent of the normal Fe\u2010uptake system. One of the four\n                          <jats:italic>\n                            <jats:styled-content style=\"fixed-case\">FRO<\/jats:styled-content>\n                          <\/jats:italic>\n                          genes in the melon and cucumber (\n                          <jats:italic>Cucumis sativus<\/jats:italic>\n                          ) genomes was Fe\u2010regulated, and one was Cu\u2010regulated. Simultaneous Fe and Cu deficiency synergistically up\u2010regulated Fe\u2010uptake gene expression.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Overlap in Fe and Cu deficiency transcriptomes highlights the importance of Fe\u2013Cu crosstalk in metal homeostasis. The\n                          <jats:italic>fefe<\/jats:italic>\n                          gene is not orthologous to\n                          <jats:italic>\n                            <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>\n                          <\/jats:italic>\n                          , and thus identification of this gene will provide clues to help understand regulation of Fe uptake in plants.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.12911","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T04:52:46Z","timestamp":1403844766000},"page":"1128-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Transcriptomic and physiological characterization of the\n                    <i>fefe<\/i>\n                    mutant of melon (\n                    <i>Cucumis melo<\/i>\n                    ) reveals new aspects of iron\u2013copper crosstalk"],"prefix":"10.1111","volume":"203","author":[{"given":"Brian M.","family":"Waters","sequence":"first","affiliation":[{"name":"Department of Agronomy and Horticulture University of Nebraska Lincoln NE  68583\u20100915 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"McInturf","sequence":"additional","affiliation":[{"name":"Department of Agronomy and Horticulture University of Nebraska Lincoln NE  68583\u20100915 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keenan","family":"Amundsen","sequence":"additional","affiliation":[{"name":"Department of Agronomy and Horticulture University of Nebraska Lincoln NE  68583\u20100915 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