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Proteins involved in different signaling pathways are the molecular basis of this concerted interplay. In our study, we show that <jats:italic>Arabidopsis thaliana <\/jats:italic><jats:styled-content style=\"fixed-case\">HEAVY METAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ASSOCIATED ISOPRENYLATED PLANT PROTEIN<\/jats:styled-content>3 (<jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3; At5g60800) acts as an upstream regulator of stress\u2010 and development\u2010related regulatory networks.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Localization, metal\u2010binding and stress\u2010responsive gene expression of <jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3 were analyzed via microscopy, protein and inductively coupled plasma (<jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> analyses and quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. In addition, transcriptome and phenotype analyses of plants overexpressing <jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3 were used to unravel its function.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our data show that <jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3 is a nuclear, zinc\u2010binding protein. It is repressed during drought stress and abscisic acid (<jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>) treatment and, similar to other pathogen\u2010related genes, is induced after infection with <jats:italic>Pseudomonas syringae<\/jats:italic> pv.\u00a0<jats:italic>tomato<\/jats:italic>. <jats:italic><jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3<\/jats:italic> overexpression affects the regulation of &gt;\u00a0400 genes. Strikingly, most of these genes are involved in pathogen response, especially in the salicylate pathway. In addition, many genes of abiotic stress responses and seed and flower development are affected by <jats:italic><jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3<\/jats:italic> overexpression. Plants overexpressing <jats:italic><jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3<\/jats:italic> show delayed flowering.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We conclude that <jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>3 acts via its bound zinc as an upstream regulator of the salicylate\u2010dependent pathway of pathogen response and is also involved in abiotic stress responses and seed and flower development.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.13419","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T11:14:58Z","timestamp":1429874098000},"page":"1084-1096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The zinc\u2010binding nuclear protein <scp>HIPP<\/scp>3 acts as an upstream regulator of the salicylate\u2010dependent plant immunity pathway and of flowering time in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"207","author":[{"given":"Wiebke","family":"Zschiesche","sequence":"first","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Barth","sequence":"additional","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Daniel","sequence":"additional","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"B\u00f6hme","sequence":"additional","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Rausche","sequence":"additional","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Humbeck","sequence":"additional","affiliation":[{"name":"Institute of Biology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Weinbergweg 10 06120 Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ern363"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12159"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/415977a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-008-9419-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0031-9317.2004.00325.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0031-9317.2001.1140112.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211592"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12035"},{"key":"e_1_2_6_10_1","first-page":"22","article-title":"Sugars, the clock and transition to flowering","volume":"4","author":"Bolouri Moghaddam MR","year":"2013","journal-title":"Frontiers in Plant Science"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2697"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.008"},{"key":"e_1_2_6_14_1","first-page":"942","article-title":"Short technical reports. 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