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Although its significant influence on plant immunity is well known, information about the exact regulatory mechanisms and signaling pathways involved in the defense response to pathogens is still limited.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We used genetic, biochemical, pharmacological approaches in combination with infection experiments to investigate the <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\u2010triggered salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>)\u2010dependent defense response in <jats:italic>Arabidopsis thaliana<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> donor S\u2010nitrosoglutathione (<jats:styled-content style=\"fixed-case\">GSNO<\/jats:styled-content>) promoted the nuclear accumulation of NONEXPRESSOR OF PATHOGENESIS\u2010RELATED GENES 1 (NPR1) protein accompanied by an elevated <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> concentration and the activation of pathogenesis\u2010related (<jats:italic>PR<\/jats:italic>) genes, leading to induced resistance of <jats:italic>A. thaliana<\/jats:italic> against <jats:italic>Pseudomonas<\/jats:italic> infection. Moreover, <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> induced a rapid change in the glutathione status, resulting in increased concentrations of glutathione, which is required for <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> accumulation and activation of the <jats:styled-content style=\"fixed-case\">NPR<\/jats:styled-content>1\u2010dependent defense response.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our data imply crosstalk between <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> and glutathione, which is integral to the <jats:styled-content style=\"fixed-case\">NPR<\/jats:styled-content>1\u2010dependent defense signaling pathway, and further demonstrate that glutathione is not only an important cellular redox buffer but also a signaling molecule in the plant defense response.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.13502","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T13:42:39Z","timestamp":1434721359000},"page":"860-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Crosstalk between nitric oxide and glutathione is required for NONEXPRESSOR OF PATHOGENESIS\u2010RELATED GENES 1 (<scp>NPR<\/scp>1)\u2010dependent defense signaling in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"208","author":[{"given":"Izabella","family":"Kovacs","sequence":"first","affiliation":[{"name":"Institute of Biochemical Plant Pathology Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health D\u201085764 Munich\/Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Durner","sequence":"additional","affiliation":[{"name":"Institute 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