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In the present study, the impacts of <jats:italic>lpa<\/jats:italic> mutations on grain composition and underlying molecular mechanisms were investigated.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Comparative compositional analyses and metabolite profiling demonstrated that concentrations of both phytic acid (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) and total phosphorus (P) were significantly reduced in <jats:italic>lpa<\/jats:italic> brown rice, accompanied by changes in other metabolites and increased concentrations of nutritionally relevant compounds. The <jats:italic>lpa<\/jats:italic> mutations modified the expression of a number of genes involved in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> metabolism, as well as in sulfate and phosphate homeostasis and metabolism.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Map\u2010based cloning and complementation identified the underlying <jats:italic>lpa<\/jats:italic> gene to be <jats:italic>Os<jats:styled-content style=\"fixed-case\">SULTR<\/jats:styled-content>3;3<\/jats:italic>. The promoter of <jats:italic>Os<jats:styled-content style=\"fixed-case\">SULTR<\/jats:styled-content>3;3<\/jats:italic> is highly active in the vascular bundles of leaves, stems and seeds, and its protein is localized in the endoplasmic reticulum. No activity of Os<jats:styled-content style=\"fixed-case\">SULTR<\/jats:styled-content>3;3 was revealed for the transport of phosphate, sulfate, inositol or inositol 1,4,5 triphosphate by heterologous expression in either yeast or <jats:italic>Xenopus<\/jats:italic> oocytes.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The findings reveal that Os<jats:styled-content style=\"fixed-case\">SULTR<\/jats:styled-content>3;3 plays an important role in grain metabolism, pointing to a new route to generate value\u2010added grains in rice and other cereal crops.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.13969","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T14:55:22Z","timestamp":1461596122000},"page":"926-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Disruption of <i>Os<scp>SULTR<\/scp>3;3<\/i> reduces phytate and phosphorus concentrations and alters the metabolite profile in rice grains"],"prefix":"10.1111","volume":"211","author":[{"given":"Haijun","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rice Biology Institute of Crop Sciences Zhejiang University Hangzhou 310058 China"},{"name":"Hubei Collaborative Innovation Center for Grain Industry Jingzhou 434025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Frank","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Allgemeine Lebensmitteltechnologie Technische Universit\u00e4t M\u00fcnchen Maximum\u2010von\u2010Imhof\u2010Forum 2 Freising\u2010Weihenstephan D\u201085354 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology Institute of Crop Sciences Zhejiang University Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Allgemeine Lebensmitteltechnologie Technische Universit\u00e4t M\u00fcnchen Maximum\u2010von\u2010Imhof\u2010Forum 2 Freising\u2010Weihenstephan D\u201085354 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Jabnoune","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology, Biophore University of Lausanne Lausanne CH\u20101015 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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