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Although the developmental regulation of flavonoid accumulation in<jats:italic>Arabidopsis thaliana<\/jats:italic>has been examined in great detail, the response of the flavonoid synthesis pathway to abiotic stress (particularly low temperature) remains unclear.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>A screen of a Dissociation element (<jats:italic>Ds<\/jats:italic>) transposon\u2010induced mutation collection identified two lines which exhibited an altered profile of phenylpropanoid accumulation following exposure to low\u2010temperature stress. One of the mutated genes (<jats:italic>BRASSINOSTEROID ENHANCED EXPRESSION1<\/jats:italic>(<jats:italic>BEE1<\/jats:italic>)) encoded a brassinosteroid enhanced expression transcription factor, while the other (<jats:italic>G2\u2010LIKE FLAVONOID REGULATOR<\/jats:italic>(<jats:italic>GFR<\/jats:italic>)) encoded a G2\u2010like flavonoid regulator. Phenylpropanoid\u2010targeted analysis was performed using high\u2010performance LC\u2010MS, and gene expression analysis using quantitative reverse transcription\u2212PCR.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In both mutants, the accumulation of quercetins and scopolin was reduced under low\u2010temperature growing conditions, whereas that of anthocyanin was increased.<jats:italic>BEE1<\/jats:italic>and<jats:italic>GFR<\/jats:italic>were both shown to negatively regulate anthocyanin accumulation by inhibiting anthocyanin synthesis genes via the suppression of the bHLH (<jats:italic>TRANSPARENT TESTA8<\/jats:italic>(<jats:italic>TT8<\/jats:italic>) and<jats:italic>GLABROUS3<\/jats:italic>(<jats:italic>GL3<\/jats:italic>)) and\/or the MYB (<jats:italic>PRODUCTION OF ANTHOCYANIN PIGMENTS2<\/jats:italic>(<jats:italic>PAP2<\/jats:italic>)) components of the MBW complex.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Our results provide new insight into the regulatory control of phenylpropanoid metabolism at low temperatures, and reveal that<jats:italic>BEE1<\/jats:italic>and<jats:italic>GFR<\/jats:italic>act as important components of the signal transduction chain.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1111\/nph.13986","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T14:25:22Z","timestamp":1462026322000},"page":"912-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["<i>Arabidopsis thaliana<\/i>G2\u2010LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low\u2010temperature regulators of flavonoid accumulation"],"prefix":"10.1111","volume":"211","author":[{"given":"Antonios","family":"Petridis","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology Leibniz Institute for Plant Genetics and Crop Plant Research Corrensstra\u00dfe 3 D\u201006466 Gatersleben 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