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Recent research provides an increasing body of evidence for papain\u2010like cysteine proteases (\n PLCP<\/jats:styled-content>\n s) being central hubs in plant immunity.\n PLCP<\/jats:styled-content>\n s are required for full resistance of plants to various pathogens. At the same time,\n PLCP<\/jats:styled-content>\n s are targeted by secreted pathogen effectors to suppress immune responses. Consequently, they are subject to a co\u2010evolutionary host\u2013pathogen arms race. When activated,\n PLCP<\/jats:styled-content>\n s induce a broad spectrum of defense responses including plant cell death. While the important role of\n PLCP<\/jats:styled-content>\n s in plant immunity has become more evident, it remains largely elusive how these enzymes are activated and which signaling pathways are triggered to orchestrate different downstream responses.\n <\/jats:p>\n \n \n \n \n \n \n \n \n \n Contents<\/jats:th>\n \n <\/jats:tr>\n <\/jats:thead>\n \n \n \n Summary<\/jats:td>\n 902<\/jats:td>\n <\/jats:tr>\n \n I.<\/jats:td>\n \n Introduction<\/jats:ext-link>\n <\/jats:td>\n 902<\/jats:td>\n <\/jats:tr>\n \n II.<\/jats:td>\n \n Depletion of PLCPs hampers plant immunity<\/jats:ext-link>\n <\/jats:td>\n 903<\/jats:td>\n <\/jats:tr>\n \n III.<\/jats:td>\n \n PLCPs are common targets of pathogen effectors<\/jats:ext-link>\n <\/jats:td>\n 903<\/jats:td>\n <\/jats:tr>\n \n IV.<\/jats:td>\n \n PLCPs induce defense responses and cell death<\/jats:ext-link>\n <\/jats:td>\n 903<\/jats:td>\n <\/jats:tr>\n \n V.<\/jats:td>\n \n PLCPs can act as co\u2010receptors<\/jats:ext-link>\n <\/jats:td>\n 905<\/jats:td>\n <\/jats:tr>\n \n VI.<\/jats:td>\n \n Natural variation in PLCPs is caused by arms races and host adaptation<\/jats:ext-link>\n <\/jats:td>\n 905<\/jats:td>\n <\/jats:tr>\n \n VII.<\/jats:td>\n \n Conclusion: how do PLCPs activate immunity?<\/jats:ext-link>\n <\/jats:td>\n 905<\/jats:td>\n <\/jats:tr>\n \n \n \n Acknowledgements<\/jats:ext-link>\n <\/jats:td>\n 906<\/jats:td>\n <\/jats:tr>\n \n \n \n References<\/jats:ext-link>\n <\/jats:td>\n 906<\/jats:td>\n <\/jats:tr>\n <\/jats:tbody>\n <\/jats:table>\n <\/jats:table-wrap>\n <\/jats:p>","DOI":"10.1111\/nph.14117","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T06:07:29Z","timestamp":1470290849000},"page":"902-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":213,"title":["Papain\u2010like cysteine proteases as hubs in plant immunity"],"prefix":"10.1111","volume":"212","author":[{"given":"Johana C.","family":"Misas\u2010Villamil","sequence":"first","affiliation":[{"name":"Botanical Institute and Center of Excellence on Plant Sciences (CEPLAS) University of Cologne BioCenter Zuelpicher Str. 47a D\u201050674 Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renier A. 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