{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:33:27Z","timestamp":1790681607602,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/K00879X\/1"],"award-info":[{"award-number":["NE\/K00879X\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/K00879X\/1"],"award-info":[{"award-number":["NE\/K00879X\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RAPIDD programme of the Science & Technology Directorate"},{"name":"Department of Homeland Security and the Fogarty International Center"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Host susceptibility to pathogens can be shaped by genetic, ecological, and evolutionary factors. The ability to predict the spread of disease therefore requires an integrated understanding of these factors, including effects of pests on pathogen growth and competition between pathogens and commensal microbiota for host resources. We examined interactions between the leaf\u2010mining moth <jats:italic>Cameraria ohridella<\/jats:italic>, the bacterial causal agent of bleeding canker disease <jats:italic>Pseudomonas syringae<\/jats:italic> pv <jats:italic>aesculi<\/jats:italic>, and the bark\u2010associated microbiota of horse chestnut (<jats:italic>Aesculus hippocastanum<\/jats:italic>) trees.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Through surveys of &gt;\u00a0900 trees from 60 sites in the UK, we tested for ecological or life history predictors of leaf miner infestation, bleeding canker, or coinfection. Using culture\u2010independent sequencing, we then compared the bark microbiomes from 46 trees to measure the association between microbiome composition and key ecological variables, including the severity of disease.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Both pest and pathogen were found to respond to tree characteristics, but neither explained damage inflicted by the other. However, we found a clear loss of microbial diversity and associated shift in microbiome composition of trees as a function of disease.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>These results show a link between bark\u2010associated microbiota and tree health that introduces the intriguing possibility that tree microbiota play key roles in the spread of disease.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.14560","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T10:42:23Z","timestamp":1492512143000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["A signature of tree health? Shifts in the microbiome and the ecological drivers of horse chestnut bleeding canker disease"],"prefix":"10.1111","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-8496","authenticated-orcid":false,"given":"Britt","family":"Koskella","sequence":"first","affiliation":[{"name":"Department of Integrative Biology University of California Berkeley CA 94720 USA"},{"name":"Centre for Ecology and Conservation University of Exeter Penryn Campus Tremough TR11 4EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Meaden","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Conservation University of Exeter Penryn Campus Tremough TR11 4EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Crowther","sequence":"additional","affiliation":[{"name":"The University of Warwick Coventry CV4 7AL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosa","family":"Leimu","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences Oxford University Oxford OX1 3RB UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Jessica E.","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology Princeton University Princeton NJ 08544 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2004.07.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.10.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2276"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235773"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/332538a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3535"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_7_10_1","first-page":"265","article-title":"Nonparametric estimation of the number of classes in a population","volume":"11","author":"Chao A","year":"1984","journal-title":"Scandinavian Journal of Statistics"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2435.12258"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2745.2012.01960.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-21-2-0208"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2016.07.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/forestry\/cpu048"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3207(92)91201-3"},{"key":"e_1_2_7_17_1","volume-title":"Report on the national survey to assess the presence of bleeding canker of horse chestnut trees in Great Britain","author":"Forestry Commission","year":"2008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.92"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-8790.2004.00820.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2664.2005.01074.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2014.11.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.112730.110"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.13133"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2004.06.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00133-11"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.03.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2435.12089"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110474108"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.05.038"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/658991"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12213"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/505766"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/677032"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1641\/0006-3568(2006)056[0395:FERTEP]2.0.CO;2"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-371"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3794.1270"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073817"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12529"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12418"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203980"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/efp.12040"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-072910-095242"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.228"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.12.009"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2307\/2403221"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23561"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ufug.2014.01.002"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ufug.2010.11.003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-014-2235-1"},{"key":"e_1_2_7_51_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2015"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12638"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.124"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1163\/22941932-90000139"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2012.04364.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/f7050095"},{"key":"e_1_2_7_58_1","first-page":"45","volume-title":"Exotic pests of eastern forests conference proceedings","author":"Schlarbaum SE","year":"1997"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0329.2007.00539.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.12.008"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3059.2010.02354.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/03071375.2004.9747402"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/afe.12020"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00468-003-0249-z"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2014.01.011"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2632(200107)86:4\/5<501::AID-IROH501>3.0.CO;2-8"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3059.2007.01754.x"}],"container-title":["New Phytologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnph.14560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nph.14560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nph.14560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nph.14560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T19:05:02Z","timestamp":1693595102000},"score":1,"resource":{"primary":{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/10.1111\/nph.14560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/nph.14560"],"URL":"https:\/\/doi.org\/10.1111\/nph.14560","archive":["Portico"],"relation":{},"ISSN":["0028-646X","1469-8137"],"issn-type":[{"value":"0028-646X","type":"print"},{"value":"1469-8137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}