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Zinc finger proteins (ZFP<\/jats:styled-content>s) consist of a superfamily involved in multiple aspects of organ morphogenesis. However, little is known about WIP<\/jats:styled-content>\u2010type ZFP<\/jats:styled-content> function in phytohormone\u2010mediated organ growth.<\/jats:p><\/jats:list-item>\n\nUsing reverse genetics, RNA<\/jats:styled-content>\u2010seq and phytohormone quantification, we elucidated the role of a new WIP<\/jats:styled-content>\u2010type ZFP<\/jats:styled-content> from Gerbera hybrida<\/jats:italic>, GhWIP<\/jats:styled-content>2, in controlling organ growth via regulation of cell expansion.<\/jats:p><\/jats:list-item>\n\nGhWIP<\/jats:styled-content>2 localizes to the nucleus and acts as a transcriptional repressor. Constitutive overexpression of GhWIP<\/jats:styled-content>2<\/jats:italic> (GhWIP<\/jats:styled-content>2OE<\/jats:styled-content>) in both Gerbera<\/jats:italic> and Arabidopsis thaliana<\/jats:italic> caused major developmental defects associated with cell expansion, including dwarfism, short petals, scapes, and petioles. Furthermore, GhWIP<\/jats:styled-content>2OE<\/jats:styled-content> plants were hypersensitive to GA<\/jats:styled-content>, but not to ABA<\/jats:styled-content>, and showed a reduction in endogenous GA<\/jats:styled-content> and auxin, but not ABA<\/jats:styled-content> concentrations. Consistent with these observations, RNA<\/jats:styled-content>\u2010seq analysis revealed that genes involved in GA<\/jats:styled-content> and auxin signaling were down\u2010regulated, while those involved in ABA<\/jats:styled-content> signaling were up\u2010regulated in GhWIP<\/jats:styled-content>2OE<\/jats:styled-content> plants.<\/jats:p><\/jats:list-item>\n\nOur findings suggest that GhWIP<\/jats:styled-content>2 acts as a transcriptional repressor, suppressing cell expansion during organ growth by modulating crosstalk between GA<\/jats:styled-content>, ABA<\/jats:styled-content>, and auxin.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.15175","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T19:43:41Z","timestamp":1524426221000},"page":"728-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["GhWIP<\/scp>2, a WIP<\/scp> zinc finger protein, suppresses cell expansion in Gerbera hybrida<\/i> by mediating crosstalk between gibberellin, abscisic acid, and auxin"],"prefix":"10.1111","volume":"219","author":[{"given":"Guiping","family":"Ren","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Lab of Biotechnology for Plant Development School of Life Sciences South China Normal University 510631 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical Garden Shenzhen & Chinese Academy of Sciences Shenzhen 518004 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Lab of Biotechnology for Plant Development School of Life Sciences South China Normal University 510631 Guangzhou 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