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Furthermore, the <jats:italic>ubc13<\/jats:italic> mutant displayed low\u2010temperature\u2010induced and salicylic acid\u2010dependent lesion mimic phenotypes. Unlike typical lesion mimic mutants, <jats:italic>ubc13<\/jats:italic> did not enhance disease resistance against virulent bacterial and fungal pathogens, but diminished hypersensitive response and compromised effector\u2010triggered immunity against avirulent bacterial pathogens. <jats:styled-content style=\"fixed-case\">UBC<\/jats:styled-content>13 differently regulates two types of programmed cell death in response to low temperature and pathogen. The lesion mimic phenotype in the <jats:italic>ubc13<\/jats:italic> mutant is partially dependent on <jats:italic><jats:styled-content style=\"fixed-case\">SNC<\/jats:styled-content>1<\/jats:italic>. <jats:styled-content style=\"fixed-case\">UBC<\/jats:styled-content>13 interacts with an F\u2010box protein <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>1 that regulates the homeostasis of <jats:styled-content style=\"fixed-case\">SNC<\/jats:styled-content>1. However, the <jats:styled-content style=\"fixed-case\">SNC<\/jats:styled-content>1 protein level was not altered in the <jats:italic>ubc13<\/jats:italic> mutant, implying that <jats:styled-content style=\"fixed-case\">UBC<\/jats:styled-content>13 is not involved in <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>1\u2010regulated <jats:styled-content style=\"fixed-case\">SNC<\/jats:styled-content>1 protein degradation.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Taken together, our results revealed that <jats:styled-content style=\"fixed-case\">UBC<\/jats:styled-content>13 is a key regulator in plant response to low temperature and pathogens.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.15435","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:10:18Z","timestamp":1537103418000},"page":"919-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Arabidopsis <i><scp>UBC<\/scp>13<\/i> differentially regulates two programmed cell death pathways in responses to pathogen and low\u2010temperature stress"],"prefix":"10.1111","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-3981","authenticated-orcid":false,"given":"Lipu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Life Sciences Capital Normal University Beijing 100048 China"},{"name":"Department of Plant Sciences University of Saskatchewan Saskatoon SK Canada S7N 5A8"},{"name":"National Research Council Canada Saskatoon SK Canada S7N 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