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Using these hybrids, we aimed to identify how novel allohexaploids restore fertility and normal meiosis after formation.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Chromosome inheritance, genome structure, fertility and meiotic behaviour were assessed in three segregating allohexaploid populations derived from the cross (<jats:italic>B.\u00a0napus<\/jats:italic>\u00a0\u00d7\u00a0<jats:italic>B.\u00a0carinata<\/jats:italic>)\u00a0\u00d7\u00a0<jats:italic>B.\u00a0juncea<\/jats:italic> using a combination of molecular marker genotyping, phenotyping and cytogenetics.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Plants with unbalanced A\u2013C translocations in one direction (where a C\u2010genome chromosome fragment replaces an A\u2010genome fragment) but not the other (where an A\u2010genome fragment replaces a C\u2010genome fragment) showed significantly reduced fertility across all populations. Genomic regions associated with fertility contained several meiosis genes with putatively causal mutations inherited from the parents (copies of <jats:italic><jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>2<\/jats:italic> in the A genome, <jats:italic><jats:styled-content style=\"fixed-case\">PAIR<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">PRD<\/jats:styled-content>3<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">PRD<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ATK<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">KATA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">KIN<\/jats:styled-content>14a<\/jats:italic> in the B genome, and <jats:italic><jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">SMC<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">TITAN<\/jats:styled-content>8<\/jats:italic> in the C genome).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Reduced seed fertility associated with the loss of chromosome fragments from only one subgenome following homoeologous exchanges could comprise a mechanism for biased genome fractionation in allopolyploids. Pre\u2010existing meiosis gene variants present in allotetraploid parents may help to stabilize meiosis in novel allohexaploids.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.15804","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:03:08Z","timestamp":1553040188000},"page":"965-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Inherited allelic variants and novel karyotype changes influence fertility and genome stability in <i>Brassica<\/i> allohexaploids"],"prefix":"10.1111","volume":"223","author":[{"given":"Roman","family":"Gaebelein","sequence":"first","affiliation":[{"name":"Department of Plant Breeding Justus Liebig University Heinrich\u2010Buff\u2010Ring 26\u201032 Giessen 35392 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-858X","authenticated-orcid":false,"given":"Sarah 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