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Inactivating mutations of <jats:italic>BIR1<\/jats:italic> in the bir1\u20101 mutant cause strong antiviral resistance independently of constitutive cell death or SA defense priming. <jats:italic>BIR1<\/jats:italic> overexpression leads to severe developmental defects, cell death and premature death, which correlate with the constitutive activation of plant immune responses.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our findings suggest that BIR1 acts as a negative regulator of antiviral defense in plants, and indicate that RNA silencing contributes, alone or in conjunction with other regulatory mechanisms, to define a threshold expression for proper BIR1 function beyond which an autoimmune response may occur. This work provides novel mechanistic insights into the regulation of <jats:italic>BIR1<\/jats:italic> homeostasis that may be common for other plant immune components.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.15931","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:58:45Z","timestamp":1558400325000},"page":"421-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post\u2010transcriptional regulation during viral infections"],"prefix":"10.1111","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-8164","authenticated-orcid":false,"given":"Irene","family":"Guzm\u00e1n\u2010Benito","sequence":"first","affiliation":[{"name":"Departmento de Biotecnolog\u00eda Microbiana y de Plantas Centro de Investigaciones Biol\u00f3gicas CSIC 28040 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